2879-42-7

Usage

Uses

3-Chloro-2,5,6-trifluoropyridine is used as a pharmaceutical intermediate.

InChI:InChI=1/C5HClF3N/c6-2-1-3(7)5(9)10-4(2)8/h1H

Upstream product

• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 2283-11-6 hexaethylphosphoric triamide 

Downstream Products

• 851179-00-5 2-fluoro-3-chloro-5-fluoropyridine 
• 1155846-91-5 3-chloro-5-[(5-chloro-3,6-difluoropyridin-2-yl)oxy]benzonitrile 
• 944799-22-8 3,6-difluoropyridin-2-amine 

Relevant academic research and scientific papers

Reactions of polyfluoroaromatic compounds with electrophilic agents in the presence of tris(dialkylamino)phosphines 8. Replacement of fluorine by hydrogen in polyfluoroaromatic compounds

When reacted with P(NEt2)3 and a proton donor, pentafluoropyridine, 3-chlorotetrafluoropyridine, pentafluorobenzonitrile, and octafluorotoluene yield products of replacement of the fluorine atom by hydrogen at position 4. This proces

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.

Reductive transformations of organofluorine compounds: II. Hydrodechlorination of chloropolyfluoroarenes by the action of zinc

Polyfluoroarenes containing chlorine atoms in the aromatic ring and/or in the benzylic position undergo hydrodechlorination by the action of zinc in aqueous dimethylformamide. The use of Zn/Cu and addition of salts (NaCl, Na2SO4, NH4Cl) favor reductive dechlorination of the Carom - Cl bond. Polyfluorobenzotrichlorides react with excess zinc to give the corresponding CH3-substituted derivatives, otherwise CH2Cl- and CHCl2-containing compounds are formed. The reduction of C6F5CCl3 and C6F5CH2Cl with zinc in the presence of copper provides lower yields of the hydrodechlorination products and leads to formation of 1,2-bis(pentafluorophenyl)ethane.