2879-42-7

Basic information

• Product Name: 3-CHLORO-2,5,6-TRIFLUOROPYRIDINE
• Synonyms: 3-CHLORO-2,5,6-TRIFLUOROPYRIDINE;3-CHLORO-2,5,6-TRIFLUOROPYRIDINE, 98+%
• CAS NO: 2879-42-7
• Molecular Formula: C₅HClF₃N
• Molecular Weight: 167.52
• EINECS: -0
• Mol File: 2879-42-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 132-134°C
• Flash Point: 132-134°C
• Appearance: /
• Density: 1.562
• Vapor Pressure: 4.62mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -10.80±0.20(Predicted)
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 1424722
• CAS DataBase Reference: 3-CHLORO-2,5,6-TRIFLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2,5,6-TRIFLUOROPYRIDINE(2879-42-7)
• EPA Substance Registry System: 3-CHLORO-2,5,6-TRIFLUOROPYRIDINE(2879-42-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2810
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2879-42-7(Hazardous Substances Data)

Usage

Uses

3-Chloro-2,5,6-trifluoropyridine is used as a pharmaceutical intermediate.

InChI:InChI=1/C5HClF3N/c6-2-1-3(7)5(9)10-4(2)8/h1H

Upstream product

• 1735-84-8 3-chloro-2,4,5,6-tetrafluoropyridine 
• 2283-11-6 hexaethylphosphoric triamide 

Downstream Products

• 944799-22-8 3,6-difluoropyridin-2-amine 
• 1155846-91-5 3-chloro-5-[(5-chloro-3,6-difluoropyridin-2-yl)oxy]benzonitrile 
• 851179-00-5 2-fluoro-3-chloro-5-fluoropyridine 

Relevant articles and documents

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.

Reductive transformations of organofluorine compounds: II. Hydrodechlorination of chloropolyfluoroarenes by the action of zinc

Polyfluoroarenes containing chlorine atoms in the aromatic ring and/or in the benzylic position undergo hydrodechlorination by the action of zinc in aqueous dimethylformamide. The use of Zn/Cu and addition of salts (NaCl, Na2SO4, NH4Cl) favor reductive dechlorination of the Carom - Cl bond. Polyfluorobenzotrichlorides react with excess zinc to give the corresponding CH3-substituted derivatives, otherwise CH2Cl- and CHCl2-containing compounds are formed. The reduction of C6F5CCl3 and C6F5CH2Cl with zinc in the presence of copper provides lower yields of the hydrodechlorination products and leads to formation of 1,2-bis(pentafluorophenyl)ethane.