1735-84-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2,4,5,6-tetrafluoropyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of various diseases and disorders. Its unique structure and reactivity make it a valuable building block for the development of new drugs.
Used in Chemical Research:
As a fluoropyridine derivative, 3-chlorotetrafluoropyridine is utilized in chemical research for the investigation of its properties and potential applications. Its reactivity with different reagents, such as zinc and tris(diethylamino)phosphine, allows for the exploration of new chemical reactions and the development of novel compounds.
Used in Material Science:
3-Chloro-2,4,5,6-tetrafluoropyridine can be employed in the development of new materials with specific properties, such as those with enhanced stability, reactivity, or selectivity. Its unique structure and ability to form organo-zinc compounds make it a promising candidate for use in material science applications.

InChI:InChI=1/C5H3F7O/c1-3(2(6)13,4(7,8)9)5(10,11)12/h1H3

Upstream product

• 1737-93-5 3,5-dichloro-2,4,6-trifluoropyridine 
• 7789-23-3 potassium fluoride 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 
• 117204-89-4 3-chloro-2,4,5,6-tetrafluoro-1-azabicyclo<2.2.0>hexa-2,5-diene 
• 700-16-3 Pentafluoropyridine 
• 110-89-4 piperidine 

Downstream Products

• 72695-42-2 3-cyclohexyltetrafluoropyridine 
• 1541-20-4 bicyclohexyl-2,2'-diene 
• 3512-13-8 2,3,4,6-tetrafluoropyridine 
• 2879-42-7 3-chloro-2,5,6-trifluoro-pyridine 
• 1592-34-3 2,3-diethoxybutane 
• 351531-60-7 4,5-dibromo-2-(3-chloro-2,5,6-trifluoro-pyridin-4-yloxy)-phenol 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 2693-57-4 4-amino-3-chloro-2,5,6-trifluoropyridine 
• 63489-55-4 4-Amino-2,3,6-trifluoropyridine 
• 851179-00-5 2-fluoro-3-chloro-5-fluoropyridine 
• 855006-73-4 4,7-difluoro-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-imidazo[4,5-c]pyridine 
• 855006-76-7 4,7-difluoro-3-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-imidazo[4,5-c]pyridine 
• 855006-74-5 4,7-difluoro-1-(2,3,5-tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-imidazo[4,5-c]pyridine 
• 202806-40-4 3-deaza-3-fluoro-adenosine 

Relevant academic research and scientific papers

Preparation method of 4-aminopyridine compound

The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.

PHOSPHAZENIUM SALT MIXTURES CONTAINING HEXAKIS(AMINO)DIPHOSPHAZENIUM, TETRAKIS(AMINO)-PHOSPHONIUM AND POLYAMINOPHOSPAZENIUM SALTS

The invention relates to mixtures containing 5 99.5 wt. % of a compound of formula (I), 95 0.5 wt. % of a compound of formula (II) and a maximum of 10 wt. % of one of several compounds of general formula (III a), wherein A - A which are independent from each other are equal or different and represent a straight-chained or branched alkyl or alkenyl having 1 - 12 carbon atoms, cycloalkyl having 4 8 carbon atoms, an aryl having 6 -12 carbon atoms, an aralkyl having 7 - 12 carbon atoms, or A-A, A-A, A-A etc. - A-A which are independent from each other and are equal or different and are connected together directly or via O or N-A to a ring having 3 - 7 ring members, A represents an alkyl having 1 - 4 carbon atoms. X1 and/or X2 and/or X3 which are independent from each other represent a radical of formula (III b), or the radical X1 and/or X2 and/or X3 as well as a straight-chained or branched alkyl or alkenyl having 1 - 12 carbon atoms, cycloalkyl having 4 - 8 carbon atoms represent an aryl having 6 - 12 carbon atoms, an aralkyl having 7 - 12 carbon atoms, or respectively the radicals which are disposed on an identically bound nitrogen atom, e.g. A and A, A and A, A and A etc. - A and A which are independent from each other are equal or different and are connected together directly or via O or N-A to a ring having 3 - 7 ring members and A represents an alkyl having 1 - 4 carbon atoms and B represents a single-valent organic or inorganic acid radical or the equivalent of a multi-valent acid radical. The mixtures can be used as catalysts and co-catalysts for phase transfer reactions, nucleophilic substitution reactions or halogen-fluoro-exchange reactions.

METHOD FOR PRODUCING A COMPOUND CONTAINING FLUORINE VIA FLUORINE-HALOGEN EXCHANGE BY SPECIAL POLYAMINO PHOSPHAZENE CATALYSTS

The invention relates to a method for producing compounds containing fluorine by reacting a compound, which contains hydrogen that can be exchanged for fluorine, with a fluoride or with a mixture of fluorides of general formula (I): MeF, wherein Me represents an alkaline earth metal ion, an NH4+ ion or an alkali metal ion, in the presence or absence of a solvent at a temperature ranging from 60 to 260 °C. The invention is characterized in that the reaction is carried out in the presence of a compound or of a mixture of compounds of general formula (IIa) and/or (IIb), whereby X1 and/or X2 and/or X3, independent of one another, have groups of formula (llc) or other groups cited in the claims.

Preparation and reactions of 2,3,4,6-tetrafluoropyridine and its derivatives

A reliable route to 2,3,4,6-tetrafluoropyridine has been established starting from the readily available 3,5-dichlorotrifluoropyridine by halogen exchange under controlled conditions to give 3-chlorotetrafluoropyridine and its subsequent hydrodechlorination using hydrogen over palladium on alumina at 250-270°C. The formation and reactions of the 3-lithio derivative have been studied with the aim of obtaining 3,4-disubstituted trifluoropyridines. Routes to such materials have been developed and their conversion to deazapurine derivatives as potential substrates for the generation of anti-sense nucleosides are reported.

POLYHALOAROMATIC EQUILIBRATIONS

Chromium oxide is a good catalyst for scrambling halogens among polyhaloaromatic compounds.Chloropentafluorobenzene and bromopentafluorobenzene disproportionate to hexafluorobenzene and the respective tetrafluorodihalobenzenes.Pentachloro- and pentafluoropyridines produce pyridines with intermediate numbers of both types of halogens.Cyano, trifluoromethyl and a single hydrogen can be present on the aromatic rings without interfering with the chemistry.

Gas-phase Photoisomerization of 3-Chloro-2,4,5,6-tetrafluoropyridine

Continuous photolysis of 3-chloro-2,4,5,6-tetrafluoropyridine produced the isomer which underwent rearomatization to the parent molecule when heated in the gas-phase.Evidence from UV absorption spectroscopy and mass spectrometry indicated that this product was the Dewar pyridine.