287935-95-9Relevant academic research and scientific papers
Direct Hiyama Cross-Coupling of (Hetero)arylsilanes with C(sp2)-H Bonds Enabled by Cobalt Catalysis
Lu, Ming-Zhu,Ding, Xin,Shao, Changdong,Hu, Zhengsong,Luo, Haiqing,Zhi, Sanjun,Hu, Huayou,Kan, Yuhe,Loh, Teck-Peng
supporting information, p. 2663 - 2668 (2020/03/30)
We report a chelation-assisted C-H arylation of various indoles with sterically and electronically diverse (hetero)arylsilanes enabled by cost-effective Cp*-free cobalt catalysis. Key to the success of this strategy is the judicious choice of copper(II) fluoride as a bifunctional sliane activator and catalyst reoxidant. This methodology features a broad substrate scope and good functional group compatibility. The synthetic versatility of this protocol has been highlighted by the gram-scale synthesis and late-stage diversification of biologically active molecules.
Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes
Lu, Ming-Zhu,Loh, Teck-Peng,Luo, Haiqing,Hu, Zhengsong,Shao, Changdong,Kan, Yuhe
supporting information, p. 9022 - 9028 (2020/12/02)
We describe herein a regioselective palladium(II)catalyzed intermolecular hydroarylation of unactivated aliphatic alkenes with electronically and sterically diverse (hetero)arylsilanes under redox-neutral conditions. A removable bidentate 8-amino-quinoline auxiliary was readily employed to dictate the regioselectivity, prevent β-hydride elimination, and facilitate protodepalladation. This silicon-based protocol features a broad substrate scope with excellent functional group compatibility and enables an expeditious route to a variety of γ-aryl butyric acid derivatives in good yields with exclusive anti-Markovnikov selectivity.
