28795-36-0

Basic information

• Product Name: 2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE
• CAS NO: 28795-36-0
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• Mol File: 28795-36-0.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• Density: 1.26g/cm³
• Refractive Index: 1.66
• CAS DataBase Reference: 2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE(28795-36-0)
• EPA Substance Registry System: 2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE(28795-36-0)

Safety Data

• Hazardous Substances Data: 28795-36-0(Hazardous Substances Data)

Usage

General Description

2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE, also known as LGD-2226, is a chemical compound with potential pharmacological properties. It belongs to the class of imidazo[1,2-a]pyridine derivatives and has been investigated for its potential therapeutic uses in cancer treatment and immunomodulation. Studies have shown that 2-FURAN-2-YL-IMIDAZO[1,2-A]PYRIDINE exhibits antiproliferative and pro-apoptotic effects on cancer cells, making it a promising candidate for drug development in the field of oncology. Additionally, its immunomodulatory properties suggest that it may have potential applications in the treatment of autoimmune and inflammatory diseases. Further research is ongoing to explore the full range of pharmacological activities and potential therapeutic uses of this compound.

InChI:InChI=1/C11H8N2O/c1-2-6-13-8-9(12-11(13)5-1)10-4-3-7-14-10/h1-8H

Upstream product

• 98-01-1 furfural 
• 504-29-0 2-aminopyridine 
• 80521-10-4 (tosyloxy)methyl 2-furanyl ketone 
• 18649-64-4 2-ethynylfuran 
• 55984-18-4 1-(furan-2-yl)-2-iodoethanone 
• 110-86-1 pyridine 
• 68727-98-0 N'-(1-(furan-2-yl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 5034-81-1 1-(furan-2-yl)ethanone O-acetyl oxime 
• 305353-93-9 C₈H₈N₄O 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 91538-30-6 3-chloro-2-(2-furyl)pyrido<1,2-a>pyrimidin-4(4H)-one 
• 15109-94-1 1-(2-furyl)-2-bromoethanone 

Downstream Products

• 63751-66-6 2-furan-2-yl-3-(4-nitro-phenylazo)-imidazo[1,2-a]pyridine 
• 63751-65-5 2-furan-2-yl-imidazo[1,2-a]pyridine-3-carbothioic acid anilide 

Relevant articles and documents

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A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

Molecular iodine enabled generation of iminyl radicals from oximes: A facile route to imidazo[1,2-a]pyridines and its regioselective C-3 sulfenylated products from simple pyridines

An iodine promoted simple and environment friendly protocol has been developed to access imidazo[1,2-a]pyridines from unfunctionalized pyridines and oxime esters. This straightforward method efficiently converts the substrates into corresponding products affording moderate to good yields with large functional group tolerance. Additionally extensive investigation revealed that regioselective domino C-3 methyl sulfenylated imidazo[1,2-a]pyridines were also accessible first time from pyridines and oxime esters in DMSO solvent. The reaction operates through metal-free generation of iminyl radicals from easily accessible oxime esters, to build up the second heterocyclic ring on pyridines.

Iodine mediated oxidative cross coupling of 2-aminopyridine and aromatic terminal alkyne: A practical route to imidazo[1,2-: A] pyridine derivatives

A novel, transition-metal free route leading to imidazo[1,2-a]pyridine derivatives via iodine mediated oxidative coupling between 2-aminopyridine and aromatic terminal alkyne has been demonstrated. This newly developed method discloses an operationally simple way for the construction of imidazoheterocycles. Commercially available antiulcer drug zolimidine may readily be synthesized employing this method.