287959-40-4

Basic information

• Product Name: methyl 3-amino-3-(2-nitrophenyl)propionate
• Synonyms: methyl 3-amino-3-(2-nitrophenyl)propionate
• CAS NO: 287959-40-4
• Molecular Weight: 224.216
• Mol File: 287959-40-4.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-amino-3-(2-nitrophenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-amino-3-(2-nitrophenyl)propionate(287959-40-4)
• EPA Substance Registry System: methyl 3-amino-3-(2-nitrophenyl)propionate(287959-40-4)

Safety Data

• Hazardous Substances Data: 287959-40-4(Hazardous Substances Data)

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 67-56-1 methanol 
• 5678-48-8 3-amino-3-(2-nitrophenyl)propionic acid 

Downstream Products

• 1012309-41-9 C₁₈H₁₈N₂O₆ 

Relevant articles and documents

Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1)

All-trans-retinoic acid (ATRA), the biologically active metabolite of vitamin A, is used medicinally for the treatment of hyperproliferative diseases and cancers. However, it is easily metabolized. In this study, the leading compound S8 was found based on virtual screening. To improve the activity of the leading compound S8, a series of novel S8 derivatives were designed, synthesized and evaluated for their in vitro biological activities. All of the prepared compounds showed that substituting the 5-chloro-3-methyl-1-phenyl-1H-pyrazole group for the 2-tertbutyl-5-methylfuran scaffold led to a clear increase in the biological activity. The most promising compound 32, with a CYP26A1 IC50 value of 1.36 μM (compared to liarozole (IC50 = 2.45 μM) and S8 (IC50 = 3.21 μM)) displayed strong inhibitory and differentiation activity against HL60 cells. In addition, the study focused on the effect of β-phenylalanine, which forms the coordination bond with the heme of CYP26A1. These studies suggest that the compound 32 can be used as an appropriate candidate for future development.

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids

An extensive structure-activity relationship (SAR) study of 72 dipeptidyl boronic acid proteasome inhibitors constructed fromβ -amino acids is reported. SAR analysis revealed that bicyclic groups at the R1 position, 3-F substituents at the Rsu

β-alanine derivatives

The invention relates to β-alanine derivatives of formula (I), wherein Q1, Q2, Q3, Q4, R1, R2, R3, R4, R5, R6and n have the meaning as disclosed