287971-25-9Relevant academic research and scientific papers
Microbial evasion of the immune system: Structural modifications of enterobactin impair siderocalin recognition
Abergel, Rebecca J.,Moore, Evan G.,Strong, Roland K.,Raymond, Kenneth N.
, p. 10998 - 10999 (2006)
The mammalian protein siderocalin binds and inactivates the ferric complex of the bacterial siderophore enterobactin with a Kd value similar to that of the bacterial receptor FepA. However, microorganisms can evade this immune response by struc
The role of electrostatics in siderophore recognition by the immunoprotein siderocalin
Hoette, Trisha M.,Abergel, Rebecca J.,Xu, Jide,Raymond, Kenneth N.,Strong, Roland K.
experimental part, p. 17584 - 17592 (2009/07/19)
Iron is required for virulence of most bacterial pathogens, many of which rely on siderophores, small-molecule chelators, to scavenge iron in mammalian hosts. As an immune response, the human protein Siderocalin binds both apo and ferric siderophores in o
