287978-72-7

Upstream product

• 250598-85-7 3,6-anhydro-7-O-benzyl-1,2:4,5-di-O-isopropylidene-D-glycero-D-manno-heptitol 
• 100-39-0 benzyl bromide 
• 144651-34-3 3,6-anhydro-1,2:4,5-di-O-isopropylidene-D-glycero-D-manno-heptitol 
• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 

Downstream Products

• 287978-73-8 3,6-anhydro-7-O-benzyl-4,5-O-isopropylidene-1,2-bis-O-(methanesulfonyl)-D-glycero-D-manno-heptitol 
• 287978-78-3 2S,3R,4R,6R,8R/S-4-phenylmethylenoxymethyl-3,8-di-tert-butyldimethylsilyloxy-1,5-dioxabicyclo[3.3.0]octane 
• 287978-81-8 2S,3R,4R,6R,8R/S-3-acetyloxy-8-methyloxy-4-(triphenylmethylenoxy)methyl-1,5-dioxabicyclo[3.3.0]octane 
• 287978-74-9 3,6-anhydro-7-O-benzyl-1,2-dideoxy-D-altro-hept-1-enitol 
• 115936-35-1 3,6-anhydro-7-O-benzyl-1,2-dideoxy-4,5-O-isopropylidene-D-altro-hept-1-enitol 

Relevant academic research and scientific papers

Chiron approach for the synthesis of 1,5-dioxa-bicyclo[3.3.0]octane: A common template for the total synthesis of Goniofufurone and Hagen's lactones

Preparation of functionalised bicyclic intermediates 18 and 21 for the total synthesis of natural products 1-4 is described by chiron approach starting from D-mannose. As a key reaction Pd(II)Cl2 catalysed intramolecular oxidative cyclisation of hydroxy(vinyl)furan 13 to obtain 14 has been developed.