288067-35-6

Basic information

• Product Name: 4-BROMO-2-HYDROXYBENZONITRILE
• Synonyms: 4-BROMOSALICYLONITRILE;4-BROMO-2-HYDROXYBENZONITRILE;5-Bromo-2-cyanophenol;2-Hydroxy-4-bromobenzonitrile;5-Bromo-2-cyanophenol, 4-Bromosalicylonitrile;4-Bromo-2-hydroxybenzonitrile, >=98%;2-hydroxy-bromobenzonitrile;Benzonitrile, 4-bromo-2-hydroxy-
• CAS NO: 288067-35-6
• Molecular Formula: C₇H₄BrNO
• Molecular Weight: 198.02
• Product Categories: Aromatic Nitriles;Nitrile;Bromine Compounds;Nitriles;Phenols
• Mol File: 288067-35-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 295.1 °C at 760 mmHg
• Flash Point: 132.3 °C
• Appearance: /
• Density: 1.79 g/cm³
• Vapor Pressure: 0.000883mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.20±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-2-HYDROXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-HYDROXYBENZONITRILE(288067-35-6)
• EPA Substance Registry System: 4-BROMO-2-HYDROXYBENZONITRILE(288067-35-6)

Safety Data

• Hazard Codes: Xi
• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 288067-35-6(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline

InChI:InChI=1/C7H4BrNO/c8-6-2-1-5(4-9)7(10)3-6/h1-3,10H

Upstream product

• 591-20-8 3-Bromophenol 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 330793-38-9 4-bromo-2-methoxybenzonitrile 
• 105942-08-3 4-bromo-6-fluorobenzonitrile 

Downstream Products

• 1600906-13-5 4-bromo-2-(2-hydroxy-ethoxy)-benzonitrile 
• 1261494-95-4 4-bromo-2-(difluoromethoxy)benzonitrile 
• 1294507-65-5 C₁₅H₈BrNO₂ 
• 1261983-31-6 C₁₄H₉NO₃ 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 693232-03-0 2-(benzyloxy)-4-bromobenzonitrile 

Relevant articles and documents

Lewis acid-promoted site-selective cyanation of phenols

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

no abstract published

BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM

The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.