28808-26-6

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-Hydroxy-1-methyl-piperidine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medications and active pharmaceutical ingredients.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-3-Hydroxy-1-methyl-piperidine is utilized as an intermediate in the production of agrochemicals, playing a crucial role in the creation of pesticides and other agricultural chemicals that are vital for crop protection and yield enhancement.
Used in Organic Compounds Synthesis:
(R)-3-Hydroxy-1-methyl-piperidine is employed as a chiral building block in the synthesis of various organic compounds, particularly in asymmetric synthesis, where its stereochemistry is leveraged to produce enantiomerically pure products with specific biological activities.

Upstream product

• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 
• 99176-14-4 1-methyl-3-piperidinyl butyrate 
• 316353-98-7 (R)-1-methyl-3-piperidinyl butyrate 
• 3554-74-3 3-Hydroxy-1-methylpiperidine 
• 108-05-4 vinyl acetate 
• 6659-33-2 (±)-3-acetoxy-N-methylpiperidine 
• 34381-71-0 (S)-2-hydroxymethyl-1-methylpyrrolidine 

Downstream Products

• 1428555-22-9 C₁₃H₁₅F₃N₂O₃ 
• 315680-06-9 (R)-1-methylpiperidin-3-yl 2-hydroxy-2,2-diphenylacetate 
• 92842-81-4 (3R)-3-[(hydroxy)(diphenyl)acetoxy]-1,1-dimethylpiperidinium bromide 
• 1428555-14-9 C₂₁H₂₄BrF₃N₂O₅S 

Relevant academic research and scientific papers

Preparation of (R)-3-hydroxy-n-methylpiperidine, a synthetic key intermediate of (R)-mepenzolate, based on the lipase-catalyzed resolution of the racemic form

In this study, a two-step method for the gram-scale synthesis of (R)-3-hydroxy-N-methylpiperidine in 97.8% enantiomeric excess (ee) is reported. The key chiral synthetic intermediate of (R)-mepenzolate was formed in 22% yield over two steps using a commer

Simple one-pot process for the bioresolution of tertiary amino ester protic ionic liquids using subtilisin

An efficient hydrolase-catalyzed bioresolution of tertiary amino ester protic ionic liquids has been demonstrated. Protic ionic liquids have been prepared in one step from the corresponding tertiary amino alcohols by treatment with butyric anhydride. Afte

QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS

Compounds of formula (I), in salt or zwitterionic form, wherein J, L, M, R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

ORGANIC COMPOUNDS

Compounds of formula (I) in salt or zwitterionic form wherein, wherein R1, R2, R3, R4, R5, J, L and M have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Ring expansion - Formation of optically active 3-hydroxypiperidines from pyrrolidinemethanol derivatives

Treatment of pyrrolidinemethanol derivatives (-)-1, (-)-6, (-)7, 8, (- )-9, (+)-10, (-)-11, and (-)-21 with trifluoroacetic anhydride and then with Et3N afforded, after hydrolysis of the trifluoroacetyl group with NaOH, the optically active -hy