28808-26-6

Basic information

• Product Name: (R)-3-Hydroxy-1-methyl-piperidine
• Synonyms: (R)-3-Hydroxy-1-methyl-piperidine;(R)-3-Hydroxy-1-Methyl-pi...;(3R)-1-methylpiperidin-3-ol
• CAS NO: 28808-26-6
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Mol File: 28808-26-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 78-80 °C(Press: 15 Torr)
• Appearance: /
• Density: 1.005±0.06 g/cm3(Predicted)
• PKA: 14.95±0.20(Predicted)
• CAS DataBase Reference: (R)-3-Hydroxy-1-methyl-piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Hydroxy-1-methyl-piperidine(28808-26-6)
• EPA Substance Registry System: (R)-3-Hydroxy-1-methyl-piperidine(28808-26-6)

Safety Data

• Hazardous Substances Data: 28808-26-6(Hazardous Substances Data)

Usage

General Description

The chemical (R)-3-Hydroxy-1-methyl-piperidine, also known as (R)-3-Hydroxypiperidine or (R)-3-Hydroxymethylpiperidine, is a chiral organic compound with the molecular formula C6H13NO. It is a hydroxy derivative of piperidine and exists as a colorless to light yellow liquid at room temperature. (R)-3-Hydroxy-1-methyl-piperidine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a chiral building block in asymmetric synthesis. The (R)-3-Hydroxy-1-methyl-piperidine is an important chemical component in various industries due to its versatile application in the production of pharmaceuticals and other organic compounds.

Upstream product

• 3554-74-3 3-Hydroxy-1-methylpiperidine 
• 6659-33-2 (±)-3-acetoxy-N-methylpiperidine 
• 108-05-4 vinyl acetate 
• 316353-98-7 (R)-1-methyl-3-piperidinyl butyrate 
• 99176-14-4 1-methyl-3-piperidinyl butyrate 
• 34381-71-0 (S)-2-hydroxymethyl-1-methylpyrrolidine 
• 143900-43-0 tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate 

Downstream Products

• 1428555-14-9 C₂₁H₂₄BrF₃N₂O₅S 
• 1428555-22-9 C₁₃H₁₅F₃N₂O₃ 
• 315680-06-9 (R)-1-methylpiperidin-3-yl 2-hydroxy-2,2-diphenylacetate 
• 92842-81-4 (3R)-3-[(hydroxy)(diphenyl)acetoxy]-1,1-dimethylpiperidinium bromide 

Relevant articles and documents

Preparation of (R)-3-hydroxy-n-methylpiperidine, a synthetic key intermediate of (R)-mepenzolate, based on the lipase-catalyzed resolution of the racemic form

In this study, a two-step method for the gram-scale synthesis of (R)-3-hydroxy-N-methylpiperidine in 97.8% enantiomeric excess (ee) is reported. The key chiral synthetic intermediate of (R)-mepenzolate was formed in 22% yield over two steps using a commer

QUATERNARY AMMONIUM SALTS AS M3 ANTAGONISTS

Compounds of formula (I), in salt or zwitterionic form, wherein J, L, M, R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Ring expansion - Formation of optically active 3-hydroxypiperidines from pyrrolidinemethanol derivatives

Treatment of pyrrolidinemethanol derivatives (-)-1, (-)-6, (-)7, 8, (- )-9, (+)-10, (-)-11, and (-)-21 with trifluoroacetic anhydride and then with Et3N afforded, after hydrolysis of the trifluoroacetyl group with NaOH, the optically active -hy