2881-34-7Relevant academic research and scientific papers
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels
Gentles, Robert G.,Grant-Young, Katherine,Hu, Shuanghua,Huang, Yazhong,Poss, Michael A.,Andres, Charles,Fiedler, Tracey,Knox, Ronald,Lodge, Nicholas,Weaver, C. David,Harden, David G.
scheme or table, p. 5316 - 5319 (2009/05/07)
An initial SAR study on a series of apamin-displacing 2-aminothiazole KCa2 channel blockers is described. Potent inhibitors such as N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (13) are disclosed, and for select members of the series, the relationship between the observed activity in a thallium flux, a binding and a whole-cell electrophysiology assay is presented.
28. Novel thiazole-containing complexing agents and luminescence of their europium(III) and terbium(III) chelates
Mukkala, Veli-Matti,Liitti, Paeivi,Hemmilae, Ilkka,Takalo, Harri,Matachescu, Cristina,Kankare, Jouko
, p. 295 - 306 (2007/10/03)
The synthesis of novel thiazole-containing complexing agents and their luminescence properties with EuIII and TbIII ions are reported. One of these terpyridine analogues was also tested as an EuIII labelling reagent, and its luminescence properties as an antibody conjugate were studied.
