288103-00-4

Basic information

• Product Name: dimethyl 2-(4-phenoxyphenyl)malonate
• Synonyms: dimethyl 2-(4-phenoxyphenyl)malonate
• CAS NO: 288103-00-4
• Molecular Weight: 300.311
• Mol File: 288103-00-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: dimethyl 2-(4-phenoxyphenyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-(4-phenoxyphenyl)malonate(288103-00-4)
• EPA Substance Registry System: dimethyl 2-(4-phenoxyphenyl)malonate(288103-00-4)

Safety Data

• Hazardous Substances Data: 288103-00-4(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 4664-61-3 methyl [p-(phenoxy)phenyl]acetate 
• 616-38-6 carbonic acid dimethyl ester 
• 101-55-3 4-Bromodiphenyl ether 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 219311-20-3 5-(4-phenoxyphenyl)pyrimidine-2,4,6-trione 
• 288103-02-6 dimethyl 2-benzyloxymethyl-2-(4-phenoxyphenyl)malonate 
• 467468-18-4 5-(4-phenoxyphenyl)-5-(piperazin-1-yl)pyrimidine-2,4,6 (1H,3H,5H)-trione 
• 467468-09-3 5-(4-(2(-2-hydroxyethoxy)ethyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-64-8 5-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-65-9 5-(4-benzylpiperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-66-0 5-(4-butylpiperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-67-1 5-(4-acetylpiperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-68-2 5-(4-methylpiperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-69-3 5-(4-phenoxyphenyl)-5-(4-(cyclopropylmethyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-71-7 5-(4-acetyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-70-6 5-(4-benzyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-72-8 5-(4-methyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1333167-26-2 5-(1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 

Relevant articles and documents

Palladium-catalyzed arylation of diisopropyl malonate applied to the efficient synthesis of the selective MMP inhibitor 5-(4-phenoxyphenyl)-5-[4-(2-pyrimidinyl)-1-piperazinyl]barbituric acid

An efficient synthesis of the highly selective MMP inhibitor 5-(4-phenoxyphenyl)-5-[4-(2-pyrimidinyl)-1-piperazinyl]barbituric acid is reported. The title compound was prepared in three steps and 72% overall yield from 4-bromophenyl phenyl ether via an im

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors

The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.