288103-01-5

Upstream product

• 638-45-9 1-Iodohexane 
• 288103-00-4 dimethyl 2-(4-phenoxyphenyl)malonate 
• 4664-61-3 methyl [p-(phenoxy)phenyl]acetate 

Relevant academic research and scientific papers

Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors

The 5,5-disubstitutedpyrimidine-2,4,6-triones represent a new class of MMP inhibitors showing selectivity for the gelatinases A and B, collagenase-3, and human neutrophil collagenase. The SAR presented here is in good agreement with an X-ray structure of compound 5 bound to the catalytic domain of stromelysin-1. While of the barbiturate structural class, compound 5 did not show any toxic or sedative effects.

Pyrimidine-2,4,6-triones

A compound of formula I wherein R1is hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryloxy or alkylalkoxy, and R2is aryloxy, or a pharmaceutically acceptab