288144-20-7 Usage
General Description
A cell-permeable and reversible indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC50 = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-Rβ, 4.92 μM for p60c-src, and 13.3 μM for FGF-R1]. The inhibition is suggested to be competitive with respective to ATP. Also inhibits VEGF-induced (IC50 = 110 nM) and PDGF-induced (IC50 = 2.01 μM) cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC50 >100 μM).
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 288144-20-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,1,4 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 288144-20:
(8*2)+(7*8)+(6*8)+(5*1)+(4*4)+(3*4)+(2*2)+(1*0)=157
157 % 10 = 7
So 288144-20-7 is a valid CAS Registry Number.
288144-20-7Relevant articles and documents
Identification of substituted 3-[(4,5,6,7-tetrahydro-1H- indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rβ tyrosine kinases
Sun, Li,Tran, Ngoc,Liang, Congxing,Hubbard, Steve,Tang, Flora,Lipson, Kenneth,Schreck, Randall,Zhou, Yong,McMahon, Gerald,Tang, Cho
, p. 2655 - 2663 (2007/10/03)
A series of new 3-substituted indolin-2-ones containing a tetrahydroindole moiety was developed as specific inhibitors of receptor tyrosine kinases associated with VEGF-R, FGF-R, and PDGF-R growth factor receptors. These compounds were evaluated for their
