288151-69-9Relevant academic research and scientific papers
GLUCOSE TRANSPORT INHIBITORS
-
Page/Page column 129; 147; 148; 151; 152, (2015/07/07)
The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for
Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
-
Page/Page column 21, (2010/02/05)
The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I) in which: Z represents oxygen or sulfur; and R1to R7represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.
