288153-46-8Relevant academic research and scientific papers
Stereospecific synthesis of the major human metabolite of paclitaxel
Wittman, Mark D.,Kadow, John F.,Vyas, Dolatrai M.
, p. 4729 - 4731 (2007/10/03)
The stereospecific synthesis of 6-α-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-α-diol 4, obtained from paclitaxel, is converted to the 6,7-β-cyclic sulfate followed by nitrate addition and reduction to afford the title compound. (C) 2000 Elsevier Science Ltd.
