200568-20-3Relevant academic research and scientific papers
Stereospecific synthesis of the major human metabolite of paclitaxel
Wittman, Mark D.,Kadow, John F.,Vyas, Dolatrai M.
, p. 4729 - 4731 (2000)
The stereospecific synthesis of 6-α-hydroxy paclitaxel 10, the major human metabolite of paclitaxel, is described. The 6,7-α-diol 4, obtained from paclitaxel, is converted to the 6,7-β-cyclic sulfate followed by nitrate addition and reduction to afford the title compound. (C) 2000 Elsevier Science Ltd.
Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel
Wittman, Mark D.,Alstadt, Thomas J.,Kadow, John F.,Vyas, Dolatrai M.,Johnson, Kathy,Fairchild, Craig,Long, Byron
, p. 4943 - 4946 (2007/10/03)
The synthetic transposition of the 7-hydroxyl group of paclitaxel to the 6-position is described. The route presented prepares both the 6-α- and β- isomers stereospecifically. The key step of this transposition involves the stereoselective reduction of th
