28821-35-4

Usage

Uses

Used in Pharmaceutical Industry:
3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-diol is used as a pharmaceutical excipient for its ability to increase the water solubility of hydrophobic drugs, improving their bioavailability and therapeutic efficacy.
Used in Cosmetic Industry:
3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-diol is used as a humectant in cosmetic formulations to help retain moisture and improve the skin's hydration.
Used in Drug Delivery Systems:
3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-diol is used as a component in drug delivery systems to enhance the solubility and stability of therapeutic agents, allowing for controlled release and targeted delivery.
Used in Biomaterials:
3,6,9,12,15,18,21,24,27,30,33,36,39,42-Tetradecaoxatetratetracontane-1,44-diol is used in the development of biomaterials, such as hydrogels and scaffolds, for tissue engineering and regenerative medicine applications due to its biocompatibility and tunable properties.

InChI:InChI=1/C30H62O16/c31-1-3-33-5-7-35-9-11-37-13-15-39-17-19-41-21-23-43-25-27-45-29-30-46-28-26-44-24-22-42-20-18-40-16-14-38-12-10-36-8-6-34-4-2-32/h31-32H,1-30H2

Upstream product

• 4792-15-8 Pentaethylene glycol 
• 57602-02-5 1,14-dibromo-3,6,9,12-tetraoxatetradecane 

Downstream Products

• 77963-48-5 o-hydroxyphenyl 3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaoxa-44-bromotetratetracontyl ether 

Relevant academic research and scientific papers

High-purity discrete PEG-oligomer crystals allow structural insight

To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 310-helical PEG structures.

Ring-Closure Reactions. 19. Kinetics of Formation of Benzo-Crown Ethers by Intramolecular Nucleophilic Substitution. A Comparison between Poly(oxyethylene) and Polymethylene Chains

Kinetic data have been obtained for the formation of 9-, 12-, 15-, 21-, 30-, and 48-membered benzo-crown ethers by intramolecular Williamson synthesis in Me2SO-water (99:1, v/v).Comparison with earlier data for the formation of catechol polymethylene ethers provides an insight into the influence on the ease of ring closure of the replacement of methylene groups by oxygen atoms.Little or no effect occurs at ring size 9.In the next higher homologues the ease of cyclization of the poly(oxyethylene) chains is some 3 times as great as that of the polymethylene chains of similar length, but in the limit of the very long chains the two series behave much in the same way.Interestingly, literature data related to the fast, encounter-controlled reactions between end groups linked by poly(oxyethylene) and polymethylene chains reveal much the same features of the slow, activation-controlled reactions.The general picture fits in with well-established conformational arguments based on the expected strain relief due to replacement of trasannular CH...HC interactions with CH...O or O...O interactions.The oxygen atom effect turns out to be a sensitive tool for the detection of even weak strain energies in ring compounds.