28824-94-4 Usage
Uses
Used in Pharmaceutical Synthesis:
5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is utilized as a building block in the synthesis of pharmaceuticals and organic compounds. Its unique structure and reactivity contribute to the creation of diverse molecular entities with therapeutic potential.
Used in Antimicrobial Applications:
In the field of antimicrobial research, 5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is employed for its potential to combat various types of infections. Its antimicrobial properties are being explored for the development of new drugs to address the growing challenge of antibiotic resistance.
Used in Antifungal Applications:
Similarly, in antifungal applications, 5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is leveraged for its potential to inhibit fungal growth. This makes it a candidate for the development of new antifungal agents, particularly in the context of increasing drug resistance among fungal pathogens.
Used in Organic Chemistry:
5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is also used as an intermediate in organic chemistry. Its versatility in forming various molecular structures allows for the exploration of new chemical entities with potential applications in different areas of science and medicine.
Used in Drug Development:
In the pharmaceutical industry, 5-methyl-2-phenyl-1H-imidazole-4-carboxylic acid is used as a key component in drug development. Its incorporation into drug molecules can enhance their efficacy and selectivity, leading to improved treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 28824-94-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,8,2 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28824-94:
(7*2)+(6*8)+(5*8)+(4*2)+(3*4)+(2*9)+(1*4)=144
144 % 10 = 4
So 28824-94-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O2/c1-7-9(11(14)15)13-10(12-7)8-5-3-2-4-6-8/h2-6H,1H3,(H,12,13)(H,14,15)
28824-94-4Relevant academic research and scientific papers
Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution
Potter, Andrew,Oldfield, Victoria,Nunns, Claire,Fromont, Christophe,Ray, Stuart,Northfield, Christopher J.,Bryant, Christopher J.,Scrace, Simon F.,Robinson, David,Matossova, Natalia,Baker, Lisa,Dokurno, Pawel,Surgenor, Allan E.,Davis, Ben,Richardson, Christine M.,Murray, James B.,Moore, Jonathan D.
scheme or table, p. 6483 - 6488 (2010/12/18)
Pin1 is an emerging oncology target strongly implicated in Ras and ErbB2-mediated tumourigenesis. Pin1 isomerizes bonds linking phospho-serine/threonine moieties to proline enabling it to play a key role in proline-directed kinase signalling. Here we report a novel series of Pin1 inhibitors based on a phenyl imidazole acid core that contains sub-μM inhibitors. Compounds have been identified that block prostate cancer cell growth under conditions where Pin1 is essential.
Chemoselective arylamidine cyclizations: Mild formation of 2-arylimidazole-4-carboxylic acids
Yoburn, Joshua C.,Baskaran, Subramanian
, p. 3801 - 3803 (2007/10/03)
(Chemical Equation Presented) A versatile, one-pot synthesis of 2-arylimidazole-4-carboxylic acids from arylamidines and methyl-2- chloroacetoacetate is described. The transformation is chemoselective, and reaction conditions are mild. Moreover, the flexibility of the strategy offers rapid access to two important classes of biaryl compounds, both 2-arylimidazoles and 2-arylpyrimidmes, depending simply upon solvent and base selection.
