28825-11-8

Basic information

• Product Name: 5-(3-nitrophenyl)-3-phenyl-1,2,4-oxadiazole
• Synonyms: 5-(3-nitrophenyl)-3-phenyl-1,2,4-oxadiazole
• CAS NO: 28825-11-8
• Molecular Weight: 267.244
• Mol File: 28825-11-8.mol

Chemical Properties

• CAS DataBase Reference: 5-(3-nitrophenyl)-3-phenyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-nitrophenyl)-3-phenyl-1,2,4-oxadiazole(28825-11-8)
• EPA Substance Registry System: 5-(3-nitrophenyl)-3-phenyl-1,2,4-oxadiazole(28825-11-8)

Safety Data

• Hazardous Substances Data: 28825-11-8(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 100-47-0 benzonitrile 
• 645-09-0 3-nitrobenzamide 
• 1408338-14-6 C₁₄H₁₁N₃O₄ 
• 619-24-9 3-nitrobenzonitrile 
• 201230-82-2 carbon monoxide 
• 613-92-3 N-hydroxyl-benzamidine 

Relevant articles and documents

Reaction of oximes of-diketones with diphosphorous tetraiodide for preparation of oxadiazoles and nitriles

The utility of diphosphorous tetraiodide as a new, mild, condensing agent for synthesis of oxadiazole is described. These data indicate the simple dehydration of oximes to 1,2,5-oxadiazole as well as the rearrangements of oximes to normal Beckmann product 1,2,4-oxadiazole. However, mono-oxime of benzil undergoes abnormal Beckman rearrangement to benzaldehyde as major product. The described method is simple and important for the synthesis of the oxadiazoles as well as for nitriles.

Convenient one-pot synthesis of 1,2,4-oxadiazoles and 2,4,6-triarylpyridines using graphene oxide (GO) as a metal-free catalyst: Importance of dual catalytic activity

A convenient and efficient process for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles and 2,4,6-triarylpyridines has been described using an inexpensive, environmentally benign, metal-free heterogeneous carbocatalyst, graphene oxide (GO). GO plays a dual role of an oxidizing agent and solid acid catalyst for synthesizing 1,2,4-oxadiazoles and triarylpyridines. This dual catalytic activity of GO is due to the presence of oxygenated functional groups which are distributed on the nanosheets of graphene oxide. A broad scope of substrate applicability and good sustainability is offered in this developed protocol. The results of a few control experiments reveal a plausible mechanism and the role of GO as a catalyst was confirmed by FTIR, XRD, SEM, and HR-TEM analysis.

Copper-catalyzed direct synthesis of 1,2,4-oxadiazoles from amides and organic nitriles by oxidative N-O bond formation

Herein, we report the first Cu-catalyzed one-step method for the synthesis of 1,2,4-oxadiazoles from stable, less toxic, and readily available amides and organic nitriles by a rare oxidative N-O bond formation using O2 as sole oxidant. This met

PTSA-ZnCl2: An efficient catalyst for the synthesis of 1,2,4-oxadiazoles from amidoximes and organic nitriles

(Chemical Equation Presented) PTSA-ZnCl2 has been proved to be an efficient and mild catalyst for the synthesis of 3,5-disubstituted-1,2,4- oxadiazoles from amidoximes and organic nitriles.

Hypervalent iodine in synthesis. 75. A convenient synthesis of oxadiazoles by palladium-catalyzed carbonylation and cyclization of diaryliodonium salts and amidoximes

3,5-Disubstituted-1,2,4-oxadiazoles were prepared in one-pot procedure in moderate yields via the palladium-catalyzed carbonylation of diaryliodonium salts with amidoximes under one atmosphere of carbon monoxide followed by intramolecular dehydrative cycl