288251-86-5

Upstream product

• 110-85-0 piperazine 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 
• 288251-87-6 tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 

Downstream Products

• 288251-87-6 tert-butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate 
• 288251-89-8 5-nitro-2-homopiperazinebenzonitrile 
• 288252-36-8 5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-1-yl)piperazin-1-yl]benzonitrile 
• 1014816-48-8 2-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-5-nitro-benzonitrile 
• 1163126-78-0 5-nitro-2-(4-(-phenyl(pyridin-4-yl)methyl)piperazin-1-yl)benzonitrile 
• 761420-13-7 2-(4-benzhydryl-piperazin-1-yl)-5-nitro-benzonitrile 
• 1163126-80-4 5-nitro-2-(4-(phenyl(pyridin-3-yl)methyl)piperazin-1-yl)benzonitrile 
• 1163126-76-8 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-5-nitrobenzonitrile 
• 1163126-50-8 5-nitro-2-(4-(oxazol-2-yl(phenyl)methyl)piperazin-1-yl)benzonitrile 
• 288251-85-4 tert-butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate 
• 288250-26-0 4-(4-{2-cyano-4-[1-(4-fluorophenyl)-5-methyl-4-pyrazolecarboxamide]phenyl}piperazin-1-yl)butyric acid hydrochloride 
• 288250-31-7 N-{3-cyano-4-[4-(2-cyano-3-hydroxycrotonoyl)piperazin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-18-0 ethyl 4-(4-{2-cyano-4-[1-(4-fluorophenyl)-5-methyl-4-pyrazolecarboxamide]phenyl}piperazin-1-yl)butyrate 
• 288250-30-6 N-{3-cyano-4-[4-(5-methylisoxazol-4-ylcarbonyl)piperazin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 

Relevant academic research and scientific papers

N-benzyl-N-aryl sulfonamide derivative as well as preparation and application thereof

The invention provides an N-Benzyl-N-Aryl sulfonamide derivative, wherein the N-Benzyl-N-Aryl sulfonamide derivatives include pharmaceutically acceptable salts and/or solvates thereof. The N-Benzyl-N-Aryl sulfonamide derivatives is obtained by condensatio

PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and / or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists

The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst1 receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst1 affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst1 affinities and >10,000-fold selectivities over the sst2 receptor subtype as well as promising pharmacokinetic properties.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring

The present invention is directed to novel 1-(N-phenylaminoalkyl)piperazine derivatives substituted at the position 2 of the phenyl ring. Pharmaceutical compositions comprising the compounds of the invention also are contemplated. The compounds of the pre