288252-08-4

Basic information

• Product Name: 5-amino-2-(2,2,2-trifluoroethoxy)benzonitrile
• CAS NO: 288252-08-4
• Molecular Weight: 216.163
• Mol File: 288252-08-4.mol

Chemical Properties

• CAS DataBase Reference: 5-amino-2-(2,2,2-trifluoroethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-2-(2,2,2-trifluoroethoxy)benzonitrile(288252-08-4)
• EPA Substance Registry System: 5-amino-2-(2,2,2-trifluoroethoxy)benzonitrile(288252-08-4)

Safety Data

• Hazardous Substances Data: 288252-08-4(Hazardous Substances Data)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 84328-69-8 5-nitro-2-(2,2,2-trifluoroethoxy)benzonitrile 

Downstream Products

• 288249-65-0 N-[3-cyano-4-(2,2,2-trifluoroethyl)phenyl]-1-(4-fluorophenyl)pyrrole-3-carboxamide 
• 288252-09-5 5-amino-2-(4-tert-butyldimethylsilyloxypiperidino)benzonitrile 

Relevant articles and documents

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.