288254-70-6

Basic information

• Product Name: 5-methyl-3-(phenylethynyl)-2-pyridinylamine
• Synonyms: 5-methyl-3-(phenylethynyl)-2-pyridinylamine
• CAS NO: 288254-70-6
• Molecular Weight: 208.263
• Mol File: 288254-70-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-methyl-3-(phenylethynyl)-2-pyridinylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-3-(phenylethynyl)-2-pyridinylamine(288254-70-6)
• EPA Substance Registry System: 5-methyl-3-(phenylethynyl)-2-pyridinylamine(288254-70-6)

Safety Data

• Hazardous Substances Data: 288254-70-6(Hazardous Substances Data)

Upstream product

• 17282-00-7 3-bromo-5-methylpyridin-2-amine 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Expedient copper-free one-pot alkynylation-cyclization sequence for the preparation of 2-substituted 7-azaindoles

Abstract 2-Substituted 7-azaindoles are rapidly and efficiently prepared in a one-pot copper-free alkynylation-cyclization sequence starting from 2-aminopyridyl halides and terminal alkynes. Most importantly the amino nitrogen atom neither requires activation nor protection throughout the sequence.

A facile and efficient synthesis of 7-azaindoles

A practical and efficient synthesis of 2-substituted 7-azaindoles has been developed using a cross-coupling-heteroannulation approach.

Synthesis of polyfunctional indoles and related heterocycles mediated by cesium and potassium bases

A general preparation of 2-substituted indoles starting from functionalized 2-alkynylanilines has been developed. This base mediated reaction has also been used to synthesize the heterocyclic core of the marine alkaloid hinckdentine A. Furthermore the reaction was successfully adapted to the solid phase. Benzofurans and isoindolones could also be prepared with this method.