17282-00-7

Basic information

• Product Name: 2-Amino-3-bromo-5-methylpyridine
• Synonyms: 3-Bromo-5-methyl-2-pyridinamine;TIMTEC-BB SBB000261;AURORA KA-7917;BUTTPARK 33\04-66;2-AMINO-5-METHYL-3-BROMO PYRIDINE;2-AMINO-3-BROMO-5-PICOLINE;2-AMINO-3-BROMO-5-METHYLPYRIDINE;6-AMINO-5-BROMO-3-PICOLINE
• CAS NO: 17282-00-7
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• EINECS: -0
• Product Categories: blocks;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridine;Bromopyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Amino-pyridine series;Amines;Heterocycles;amine|alkyl bromide
• Mol File: 17282-00-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 73-76 °C(lit.)
• Boiling Point: 252.348 °C at 760 mmHg
• Flash Point: 106.417 °C
• Appearance: Yellow to beige or brown/Crystalline Powder
• Density: 1.5672 (rough estimate)
• Vapor Pressure: 0.0194mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.28±0.49(Predicted)
• Water Solubility: Insoluble
• BRN: 471829
• CAS DataBase Reference: 2-Amino-3-bromo-5-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-5-methylpyridine(17282-00-7)
• EPA Substance Registry System: 2-Amino-3-bromo-5-methylpyridine(17282-00-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 17282-00-7(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

Uses

Different sources of media describe the Uses of 17282-00-7 differently. You can refer to the following data:
1. 2-Amino-3-bromo-5-methylpyridine is used for the preparation of imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrazines, imidazo[1,2-c]pyrimidines, and imidazo[1,2-d]triazines as JNK and ERK kinase inhibitors
2. 2-Amino-3-bromo-5-methylpyridine may be used in the synthesis of:3-bromo-2-chloro-5-methylpyridine3-bromo-2-fluoro-5-methylpyridine8-methyl-1,2,3,5-tetrahydropyrido[3,4-b][1,4]diazepin-4-one3-bromo-2-(ethylamino)-5-methylpyridine(3-bromo-5-methylpyridin-2-yl)aniline5-methyl-3-(phenylethynyl)pyridin-2-amine3-[(2-methoxyphenyl)ethynyl]-5-methylpyridin-2-amine3-[(4-methoxyphenyl)ethynyl]-5-methylpyridin-2-amine3-[(3-chlorophenyl)ethynyl]-5-methylpyridin-2-amine

InChI:InChI=1/C6H7BrN2/c1-4-2-5(7)6(8)9-3-4/h2-3H,1H3,(H2,8,9)/p+1

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Downstream Products

• 136117-93-6 8-bromo-6-methyl-imidazo<1,2-a>pyridine 
• 155790-02-6 3-Bromo-5-methyl-2-nitro-pyridine 
• 17282-03-0 3-bromo-2-chloro-5-methyl-pyridine 
• 288254-70-6 5-methyl-3-(phenylethynyl)-2-pyridinylamine 
• 872492-59-6 N-(3-bromo-5-methylpyridin-2-yl)-N-methylamine 
• 901124-75-2 8-bromo-2-(chloromethyl)-6-methylimidazo[1,2-a]pyridine 
• 20348-17-8 5-methyl-2-amino-3-pyridinol 
• 690956-59-3 N-(3-bromo-5-methylpyridin-2-yl)benzamide 
• 349401-64-5 4-methoxy-N-(5-methylpyridin-2-yl)benzamide 
• 1203571-75-8 8-bromo-6-methylimidazo[1,2-a]pyridine-2-carboxylic acid 
• 1261061-25-9 (S)-2-benzyl-7-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one 
• 351001-77-9 5-methyl-3-phenylpyridine-2-amine 

Relevant articles and documents

Synthesizing method of (E)-5-methyl-1H-pyrrolo-[2,3-b] pyridine-3-formaldoxime

The invention relates to a synthesizing method of (E)-5-methyl-1H-pyrrolo-[2,3-b] pyridine-3-formaldoxime, which solves the technical problem that an effective synthesizing method is not discovered at present. The synthesizing method provided by the invention comprises the following steps: brominating 2-amino-5-picoline, so as to obtain a compound 1; performing a reaction on the compound 1 and trimethylsilylacetylene under a condition of a Sonogashira coupling reaction, so as to generate a compound 2; performing a reaction on the compound 2 and sodium hydride to form a pyrrole ring, so as to generate a compound 3; performing a reaction on the compound 3 and urotropine, so as to generate a compound 4; performing the compound 4, hydroxylamine hydrochloride and sodium acetate, so as to obtain the target product (E)-5-methyl-1H-pyrrolo-[2,3-b] pyridine-3-formaldoxime. As a sodium acetate, the (E)-5-methyl-1H-pyrrolo-[2,3-b] pyridine-3-formaldoxime is widely applied in the pharmaceutical industry.

Synthesis and study of nucleic acids interactions of novel monomethine cyanine dyes

Six asymmetric monomethine cyanine dyes have been synthesized and their spectral characteristics and interaction with double stranded (ds)DNA have been investigated for their prospective use as fluorescent markers in molecular biology. Therefore, the non-covalent binding of the compounds with dsDNA was explored. Apart from the fluorescence spectroscopy, the study includes UV/Vis spectrophotometry and circular dichroism spectroscopy, as well as the thermal melting experiments. Although the compounds show relatively low binding affinity toward dsDNA and do not have intrinsic fluorescence, in the presence of dsDNA they exhibited considerable enhancement in fluorescence intensity. Therefore the studied dyes show interesting platform for future modifications directed toward more sequence selective derivatives. The compound with the highest affinity toward dsDNA showed interesting anti-proliferative potential and specificity.

ADAMANTYL DERIVATES AS P2X7 RECEPTOR ANTAGONISTS

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