288309-53-5 Usage
Uses
Used in Pharmaceutical Industry:
3-Cyanophenylzinc Iodide is used as a reagent/substrate for the palladium-catalyzed synthesis of 5-substituted 2-furaldehydes, which are of biological importance. These compounds have potential applications in the development of new drugs and therapeutic agents, as they can be used as building blocks for the synthesis of various bioactive molecules.
Used in Chemical Synthesis:
3-Cyanophenylzinc Iodide is used as a substrate in the di-functionalization of indenes via α-carbonylalkylarylation. This process results in the formation of α-carbonyl-alkylarylated indenes, which are valuable intermediates in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials.
Check Digit Verification of cas no
The CAS Registry Mumber 288309-53-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,3,0 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 288309-53:
(8*2)+(7*8)+(6*8)+(5*3)+(4*0)+(3*9)+(2*5)+(1*3)=175
175 % 10 = 5
So 288309-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H4N.HI.Zn/c8-6-7-4-2-1-3-5-7;;/h1-2,4-5H;1H;/q-1;;+2/p-1/rC7H4N.IZn/c8-6-7-4-2-1-3-5-7;1-2/h1-2,4-5H;/q-1;+1
288309-53-5Relevant academic research and scientific papers
Nickel-Catalyzed α-Carbonylalkylarylation of Vinylarenes: Expedient Access to γ,γ-Diarylcarbonyl and Aryltetralone Derivatives
Dhungana, Roshan K.,Giri, Ramesh,Khanal, Namrata,Shekhar, K. C.
supporting information, p. 8047 - 8051 (2020/04/30)
We report a Ni-catalyzed regioselective α-carbonylalkylarylation of vinylarenes with α-halocarbonyl compounds and arylzinc reagents. The reaction works with primary, secondary, and tertiary α-halocarbonyl molecules, and electronically varied arylzinc reagents. The reaction generates γ,γ-diarylcarbonyl derivatives with α-secondary, tertiary, and quaternary carbon centers. The products can be readily converted to aryltetralones, including a precursor to Zoloft, an antidepressant drug.
