28832-02-2

Upstream product

• 6081-61-4 N-(benzyloxycarbonyl)-D-serine 
• 501-53-1 benzyl chloroformate 
• 68-41-7 cycloserine 

Downstream Products

• 53459-37-3 ((R)-2-carbamoyl-3-oxo-isoxazolidin-4-yl)-carbamic acid benzyl ester 
• 28832-06-6 ((R)-2-benzhydryl-3-oxo-isoxazolidin-4-yl)-carbamic acid benzyl ester 
• 82933-40-2 [(R)-2-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionyl)-3-oxo-isoxazolidin-4-yl]-carbamic acid benzyl ester 
• 82933-39-9 (R)-2-Benzyloxycarbonylamino-3-((S)-2-benzyloxycarbonylamino-3-hydroxy-propionylaminooxy)-propionic acid methyl ester 
• 1436858-00-2 (R)-butyl-4-{[(benzyloxy)carbonyl]amino}-3-oxoisoxazolidine-2-carboxylat 
• 82933-38-8 α-((benzyloxy)carbonyl)-β-aminoxy-D-alanine methyl ester hydrochloride 
• 28832-03-3 ((R)-2-benzyl-3-oxo-isoxazolidin-4-yl)-carbamic acid benzyl ester 
• 28832-05-5 [(R)-2-(4-chloro-butyl)-3-oxo-isoxazolidin-4-yl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

An efficient and facile synthesis of D-cycloserine substantially free from potential impurities

An efficient and facile synthesis of D-cycloserine has been developed from D-serine with 61% overall yield employing protectiondeprotection strategy. Different parameters affecting the impurities content and yield of D-cycloserine have been studied. Mild reaction conditions provided the product with remarkable purity (>99%) and high stability.

Pharmacophore assessment through 3-D QSAR: Evaluation of the predictive ability on new derivatives by the application on a series of antitubercular agents

Pharmacophoric mapping is a useful procedure to frame, especially when crystallographic receptor structures are unavailable as in ligand-based studies, the hypothetical site of interaction. In this study, 71 pyrrole derivatives active against M. tuberculosis were used to derive through a recent new 3-D QSAR protocol, 3-D QSAutogrid/R, several predictive 3-D QSAR models on compounds aligned by a previously reported pharmacophoric application. A final multiprobe (MP) 3-D QSAR model was then obtained configuring itself as a tool to derive pharmacophoric quantitative models. To stress the applicability of the described models, an external test set of unrelated and newly synthesized series of R-4-amino-3-isoxazolidinone derivatives found to be active at micromolar level against M. tuberculosis was used, and the predicted bioactivities were in good agreement with the experimental values. The 3-D QSAutogrid/R procedure proved to be able to correlate by a single multi-informative scenario the different activity molecular profiles thus confirming its usefulness in the rational drug design approach.