288323-80-8Relevant articles and documents
Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: Stabilization of the metabolically labile vanillyl side chain
Ullrich, Thomas,Baumann, Karl,Welzenbach, Karl,Schmutz, Simone,Camenisch, Gian,Meingassner, Josef G.,Weitz-Schmidt, Gabriele
, p. 2483 - 2487 (2007/10/03)
Modification of the vanillyl substituent on a potent, semisynthetic lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 binding inhibitor of the statin family resulted in metabolically more stable analogues that displayed submicromolar inhibitory activity in vitro and considerable anti-inflammatory activity in vivo. The benzodioxole derivative 2b emerged with the best overall profile.