288372-08-7

Upstream product

• 17983-33-4 1-allyldimethylsilyl-4-bromobenzene 
• 106-37-6 1.4-dibromobenzene 
• 4028-23-3 Allylchlorodimethylsilane 
• 89524-99-2 methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetate 
• 261761-38-0 4-(allyldimethylsilyl)benzaldehyde 

Downstream Products

• 288372-10-1 (S)-methyl-3-([4-allyldimethylsilyl]naphthyl)-2-(tert-butoxycarbamido)propanoate 
• 288372-09-8 (S)-methyl-2-acetamido-3-([4-allyldimethylsilyl]phenyl)propanoate 

Relevant academic research and scientific papers

Silicon-based aromatic transferring linkers for traceless solid-phase synthesis of aryl-, polyaryl-, and heteroaryl-containing compounds

A number of arylsilane-based linkers are prepared for traceless solid-phase synthesis. General methodologies for introduction of the silyl group and various functional groups to aromatic, polyaromatic, and heteroaromatic rings are developed. Also, broad u

Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic sansalvamide a using a side-chain-tethered phenylalanine building block

(matrix presented) A 10-step solid-phase synthesis of the cytotoxic depsipeptide sansalvamide A (1) has been accomplished in an overall yield of 67% with >95% purity employing polymer-bound phenylalanine building block 2. Both the N- and C-termini of 2 are extended followed by on-resin head-to-tail macrocyclization of the linear peptide in a high yield. This should be a general stategy for the synthesis of diverse libraries of cyclic peptides and depsipeptides that contain exclusively phenylalanine and other hydrophobic side chains.