288386-04-9

Basic information

• Product Name: 4-FLUORO-5-HYDROXYINDOLE
• Synonyms: 4-FLUORO-5-HYDROXYINDOLE;1H-Indol-5-ol, 4-fluoro- (9CI);4-Fluoro-1H-indol-5-ol;4-Fluoro-5-hydroxy-1H-indole
• CAS NO: 288386-04-9
• Molecular Formula: C8H6FNO
• Molecular Weight: 151.14
• Product Categories: ALCOHOL;INDOLE;HALIDE
• Mol File: 288386-04-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 322.387 °C at 760 mmHg
• Flash Point: 148.775 °C
• Appearance: /
• Density: 1.446 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.7
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-FLUORO-5-HYDROXYINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-5-HYDROXYINDOLE(288386-04-9)
• EPA Substance Registry System: 4-FLUORO-5-HYDROXYINDOLE(288386-04-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 288386-04-9(Hazardous Substances Data)

Usage

General Description

4-Fluoro-5-hydroxyindole is a chemical compound with the molecular formula C8H6FNO and a molecular weight of 149.14 g/mol. It is a derivative of indole, a heterocyclic compound commonly found in many natural products and pharmaceuticals. 4-Fluoro-5-hydroxyindole is an intermediate in the synthesis of various pharmaceutical compounds and has potential applications in drug discovery and development. It is also used as a building block in organic synthesis for the preparation of diverse indole-based compounds. The chemical properties and biological activities of 4-fluoro-5-hydroxyindole make it a valuable tool in medicinal chemistry research and drug design.

InChI:InChI=1/C8H6FNO/c9-8-5-3-4-10-6(5)1-2-7(8)11/h1-4,10-11H

Upstream product

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Relevant articles and documents

Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease

The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

Chemical compounds

The invention relates to compounds of the formula (I): wherein: ring C is 9 or 10-membered bicyclic heteroaromatic group containing at least one nitrogen atom in the ring attached to Z and optionally containing a further 1-3 heteroatoms, selected independently from O, S, and N, with the proviso that ring C is not a quinazoline, quinoline or cinnoline group; either any one of G1, G2, G3, G4 and G5 is nitrogen and the other four are —CH—; or G1, G2, G3, G4 and G5 are all —CH—; Z is —O—, NH—, —S—, CH2— or a direct substituents R1 may be attached at any free carbon atom of the indole, azaindole or indazole group; m is an integer from 0 to 2; Rb represents hydrogen or another value as defined herein; R1 represents hydrogen, hydroxy, halogeno, C1-4alkyl, or any other value as defined herein; R2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C1-3alkyl, C1-3alkoxy, C1-3alkylsulphanyl, —NR3R4 (wherein R3 and R4, which may be the same or different, each represents hydrogen or C1-3alkyl), or R5X1— (wherein R5 and X1 are as defined herein) and salts thereof, processes for the preparation of such compounds, pharmaceutical compositions