Welcome to LookChem.com Sign In|Join Free

CAS

  • or

288579-82-8

Post Buying Request

288579-82-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

288579-82-8 Usage

General Description

1H-Benzimidazole-5-carboxaldehyde,2-chloro-(9CI) is a chemical compound with the molecular formula C9H6ClN3O. It is a chlorinated derivative of benzimidazole-5-carboxaldehyde, which is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. 1H-Benzimidazole-5-carboxaldehyde,2-chloro-(9CI) has potential applications in medicinal chemistry and drug development due to its unique structure and biological activities. It may be used as a starting material for the synthesis of various heterocyclic compounds and can also serve as a building block for the preparation of novel biologically active molecules. Additionally, it may also have uses in research and development in the pharmaceutical and agrochemical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 288579-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,8,5,7 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 288579-82:
(8*2)+(7*8)+(6*8)+(5*5)+(4*7)+(3*9)+(2*8)+(1*2)=218
218 % 10 = 8
So 288579-82-8 is a valid CAS Registry Number.

288579-82-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1H-Benzimidazole-5-carboxaldehyde,2-chloro-(9CI)

1.2 Other means of identification

Product number -
Other names 1H-BenziMidazole-6-carboxaldehyde,2-chloro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:288579-82-8 SDS

288579-82-8Downstream Products

288579-82-8Relevant articles and documents

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Rangarajan, Meera,Kim, Jung Sun,Jin, Song,Sim, Sai-Peng,Liu, Angela,Pilch, Daniel S.,Liu, Leroy F.,Lavoie, Edmond J.

, p. 1371 - 1382 (2007/10/03)

5-Phenylterbenzimidazole (1) is active as a topoisomerase I poison (topo I) and is cytotoxic to human tumor cells. No cross-resistance was observed for 1 when it was evaluated against the camptothecin-resistant cell line, CPT-K5. Derivatives of 1 substituted at the 2'-position, however, did exhibit cross-resistance to this cell line. The basis for the resistance of this cell line towards CPT is that it possesses a mutant form of topo I. These results suggest that substituents at the 2'-position may be in proximity to the wild-type enzyme. Therefore, we hypothesized that terbenzimidazoles with 2'-substituents could be capable of interacting with the enzyme and thereby influence activity within this class of topo I poisons. 5-Phenylterbenzimidazoles with a hydroxy, hydroxymethyl, mercapto, amino, N-benzoylaminomethyl, chloro, and trifluoromethyl group at the 2'-position were synthesized. In addition, several 2'-ethyl-5-phenylterbenzimidazoles were prepared containing either a methoxy, hydroxy, amino, or N-acetylamino group at the 2-position of the ethyl side-chain. These 2'-substituted 5-phenylterbenzimidazoles were evaluated as topo I poisons and for cytotoxic activity. The presence of a strong electron-withdrawing group at the 2'-position, such as a chloro or trifluoromethyl group, did enhance both topo I poisoning activity and cytotoxicity. Studies on the relative DNA binding affinity of 1 to its 2'-amino and 2'-trifluoromethyl derivatives did exhibit a correlation with their relative differences in biological activity. Copyright (C) 2000 Elsevier Science Ltd.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 288579-82-8