288587-12-2Relevant articles and documents
Pyrrolidines bearing a quaternary α-stereogenic center. Part 2: Access to proline chimeras, stereoselective approach and mechanistic aspects
Trancard, Delphine,Tout, Jean-Baptiste,Giard, Thierry,Chichaoui, Ilhame,Cahard, Dominique,Plaquevent, Jean-Christophe
, p. 3843 - 3847 (2000)
The present work describes the access to various proline chimeras bearing a quaternary α-stereogenic center, via the Duhamel ring contraction of heterocyclic enamines. Attempts to induce diastereoselectivity are reported. The 'chiral enamine' strategy aff