288588-12-5Relevant academic research and scientific papers
Synthesis of enantiopure 8-aminomethylindolizines from glutamine by stereoelectronically controlled cationic cyclization
Lehmann, Thomas,Gmeiner, Peter
, p. 1371 - 1378 (2007/10/03)
Starting from natural glutamine the synthesis of the 8- aminomethylindolizine (4b) was accomplished. The construction of the ring system was performed by employing a cationic 6-exo π-cyclization of an intermediate aziridinium salt. Transformation of the N,N-dibenzyl protected amine (4b) into the pharmacologically relevant target compound (11) is also described.
