288590-99-8

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 142144-66-9 3-cyclopent-1-enyl-phenol 
• 2398-37-0 3-methoxyphenyl bromide 
• 36742-36-6 1-(3-methoxyphenyl)cyclopentene 
• 120-92-3 cyclopentanone 
• 142144-65-8 1-(3-methoxyphenyl) cyclopentan-1-ol 

Downstream Products

• 1202643-77-3 C₁₇H₂₈OSi 
• 288591-15-1 {(2R,6S)-6-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyran-2-yl}-acetic acid methyl ester 
• 288591-14-0 (E)-(S)-7-[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-7-hydroxy-hept-2-enoic acid methyl ester 
• 288591-02-6 7-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-7-oxo-hept-2-enoic acid methyl ester 
• 288591-03-7 7-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-7-hydroxy-hept-2-enoic acid methyl ester 
• 288591-01-5 5-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-5-oxo-pentanal 

Relevant academic research and scientific papers

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

Synthesis of simplified herboxidiene aromatic hybrids

The syntheses of simplified aromatic hybrids of the novel polyketide herboxidiene (1) are described. One of the hybrids prepared showed significant herbicidal activity against broad-leaved weeds in post-emergent application. (C) 2000 Elsevier Science Ltd. All rights reserved.