28860-33-5

Basic information

• Product Name: 1,4-ditosyl-1,4-diazepan-6-ol
• Synonyms: 1,4-ditosyl-1,4-diazepan-6-ol
• CAS NO: 28860-33-5
• Molecular Formula: C₁₉H₂₄N₂O₅S₂
• Molecular Weight: 424.53426
• Mol File: 28860-33-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-ditosyl-1,4-diazepan-6-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-ditosyl-1,4-diazepan-6-ol(28860-33-5)
• EPA Substance Registry System: 1,4-ditosyl-1,4-diazepan-6-ol(28860-33-5)

Safety Data

• Hazardous Substances Data: 28860-33-5(Hazardous Substances Data)

Usage

Chemical class

Diazepine derivative

Structural features

Contains two tosyl (4-methylbenzenesulfonyl) groups

Potential applications

Pharmaceutical research and drug development

Biological activities

Not fully understood, requires further research

Health hazards

May pose health hazards if not handled properly

Precaution

Handle with caution

Further research

Needed to fully understand properties and potential uses

Upstream product

• 96-21-9 1,3-dibromo-2-hydroxypropane 
• 4403-78-5 ditosylethylenediamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 96-13-9 2,3-Dibromopropan-1-ol 
• 39547-86-9 disodium N¹,N²-ditosyl-1,2-ethanediamide 

Downstream Products

• 203722-04-7 1,4-bis(toluene-4-sulfonyl)-[1,4]diazepan-6-one 
• 529509-59-9 6,6-difluoro-1,4-bis[(4-methylbenzene)sulfonyl]-1,4-diazepane 
• 529509-58-8 6,6-difluoro-[1,4]diazepane 
• 439134-39-1 6-azido-1,4-ditosyl-1,4-diazepane 
• 439134-38-0 6-amino-1,4-ditosylperhydro-1,4-diazepine 
• 902768-87-0 1,4-ditosyl-1,4-diazepan-6-mesylate 
• 123187-92-8 1,4-bis(p-tolylsulfonyl)hexahydro-6-fluoro-1H-1,4-diazepine 

Relevant articles and documents

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and in Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance against the multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity and were addressed through structure-Activity and structure-property relationship studies. Pharmacokinetic properties were assessed in mice for compounds showing desirable in vitro activity, a selectivity window over cytotoxicity, and microsomal metabolic stability. Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rnull (NSG) mouse model. Preliminary mechanistic studies suggest inhibition of hemozoin formation as a contributing mode of action.

The coordination chemistry of 1,4-diazepan-6-amine

The new, tridentate, facially coordinating ligand 1,4-diazepan-6-amine (daza) has been prepared from ethane-1,2-diamine and 2,3-dibromo-1-propanol in a seven-step procedure with an overall yield of 22%. The conformation of the free ligand has been elucida