288608-09-3

Basic information

• Product Name: 1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole
• Synonyms: 1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole
• CAS NO: 288608-09-3
• Molecular Formula: C₁₂H₁₂IN
• Molecular Weight: 297.13485
• Mol File: 288608-09-3.mol
• Article Data: 17

Chemical Properties

• Melting Point: 82-84°
• Appearance: /
• CAS DataBase Reference: 1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole(288608-09-3)
• EPA Substance Registry System: 1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole(288608-09-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 288608-09-3(Hazardous Substances Data)

Usage

General Description

1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole is a chemical compound with the molecular formula C13H12IN. It is a pyrrole derivative that contains a pyrrole ring system with an iodine substituent on the phenyl ring. The compound is a pale yellow solid with a molecular weight of 299.15 g/mol. It is used in organic synthesis and pharmaceutical research as a building block or intermediate for the synthesis of various complex organic molecules. The chemical structure of 1-(4-iodophenyl)-2,5-dimethyl-1H-pyrrole makes it useful for applications in the field of materials science and drug discovery.

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 110-13-4 2,5-hexanedione 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 570-05-8 2,5-dimethyl-1-(4-(trifluoromethyl)phenyl)-1H-pyrrole 
• 1377182-47-2 1,4-bis{2-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]ethynyl}-2,5-dihexylbenzene 
• 1377182-45-0 1,4-bis[2-(4-iodophenyl)ethynyl]-2,5-dihexylbenzene 
• 60200-91-1 4-chloro-4'-iodo-1,1'-biphenyl 
• 29170-08-9 4-iodo-4'-nitrobiphenyl 
• 936217-16-2 1-(2,5-dimethyl-1H-pyrrol-1-yl)-4''-nitro-4,1':4',1''-terphenylene 
• 936217-11-7 4-(2,5-dimethyl-1H-pyrrol-1-yl)-4'-cyanobiphenyl 

Relevant articles and documents

Catalytic applications of nano β-PbO in Paal-Knorr reaction

Several 2,5-dimethyl-N-substituted pyrroles were prepared by the condensation of different substituted anilines with 2,5-hexanedione using nano lead oxide as an efficient and recyclable catalyst. All the synthesized compounds are confirmed through IR, 1H NMR, 13C NMR and mass spectral data. Nano lead oxide β-PbO (P85) was prepared by dissolving lead acetate dihydrate in 1-propanol at a pH 9.0 under stirring at 85 °C. The structural study and surface morphology of the lead oxide (PbO) were characterized using X-ray diffraction (XRD), Scanning electron microscopy (SEM) and the functional groups of the PbO sample were investigated using infrared spectrophotometer.

Imidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones

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Copper-catalyzed and additive free decarboxylative trifluoromethylation of aromatic and heteroaromatic iodides

A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional group tolerance and is compatible with heteroaromatic systems. The reaction proved scalable to a 15 mmol scale with increased yield. Finally, late-stage installation of the trifluoromethyl functionality afforded the N-trifluoroacetamide variant of the antidepressant agent, Prozac, demonstrating the applicability of the developed method.

New nano-Fe3O4-supported Lewis acidic ionic liquid as a highly effective and recyclable catalyst for the preparation of benzoxanthenes and pyrroles under solvent-free sonication

A novel magnetic nanomaterial-immobilized Lewis acidic ionic liquid was successfully synthesized by the covalent embedding of 3-(3-(trimethoxysilyl)propyl)-1H-imidazol-3-ium chlorozincate (ii) ionic liquid to the surface of Fe3O4 nanoparticles. The material was then characterized by FT-IR, SEM, TEM, TGA, ICP-OES, Raman, and EDS. Its performance as a new-generation Lewis acidic catalyst was also examined on the ultrasound-mediated synthesis of benzoxanthenes and pyrroles. Upon completion, the catalyst was simply recovered by an external magnet for multiple reuses without significant lessening of catalytic performance.