28862-78-4

Upstream product

• 21394-81-0 (R)-2-amino-4-methoxy-4-oxobutanoic acid 
• 501-53-1 benzyl chloroformate 
• 22728-89-8 D-2-amino-3-methoxycarbonylpropionic acid hydrochloride 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 67-56-1 methanol 
• 1783-96-6 (2R)-aspartic acid 

Downstream Products

• 1041438-89-4 C₂₄H₃₀N₂O₇ 
• 77856-52-1 (S)-3-<(benzyloxycarbonyl)amino>-4-(methoxycarbonyl)butyric acid 
• 149967-09-9 N-<(phenylmethoxy)carbonyl>-O-<(1,1-dimethylethyl)dimethylsilyl>-D-homoserine, 1,1-dimethylethyl ester 
• 149967-07-7 N-<(phenylmethoxy)carbonyl>-D-aspartic acid, 1,1-dimethylethyl ester 
• 149967-08-8 N-<(phenylmethoxy)carbonyl>-D-homoserine, 1,1-dimethylethyl ester 
• 186909-94-4 {(R)-4-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]-3-methoxycarbonylmethyl-2-oxo-piperazin-1-yl}-acetic acid 
• 149967-06-6 N-<(phenylmethoxy)carbonyl>-D-aspartic acid, 1-(1,1-dimethylethyl) 4-methyl ester 

Relevant academic research and scientific papers

A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS

The invention is a process for preparing a diazabicyclo compound of formula (I) process for preparing a diazabicyclo compound of formula (I):where X is selected from the group consisting of hydrogen, C1-C6 alkoxycarbonyl, and carbobenzyloxy; R6 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, and benzyl; and R9, R 10, and R11 are independently selected from the group consisting of hydrogen, halogen, and C1-C6 alkyl. wherein the process involves cyclizing I-I, formula (II).

Asymmetric Synthesis of 3-Carboxyproline and Derivatives Suitable for Peptide Synthesis

An asymmetric synthesis of both diastereomers of 3-carboxyproline, as well as 5-substituted derivatives and partially protected derivatives suitable for peptide synthesis starting from aspartic acid is reported.

Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: Modification of the P1 and P2' residues

Systematic modification of the presumed P1 side chain in a series of (carboxyalkyl)amino-based inhibitors of matrix metalloproteinases enabled identification of the 2-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)ethyl group as a preferred substituent imparting potent inhibition of the enzymes collagenase and gelatinase. It was subsequently found that the P2'-P3' residues in this series could be replaced by small non-peptide residues, while maintaining inhibitory potency. The imide group in this series of compounds can undergo autocatalytic hydrolysis under neutral conditions.

Racemic Origins of the Stereochemically Homogeneous Biosphere. Biased Stereoselectivities in the Formation of Oligomeric Peptides

Each of the competitive processes used to form the 34-di-, tri-, and tetrapeptides of alanine, aspartic acid, and glycine, 3 of the most abundant amino acid products of geosimulation experiments, was found to be stereoselective.The majority of them (70per

ENANTIOSPECIFIC SYNTHESIS OF A CHIRAL CARBAPENEM PRECURSOR FROM (R)-ASPARTIC ACID

A short enantiospecific preparation of a key intermediate to carbapenem antibiotics with (R)-aspartic acid as chiral educt is described.