288623-03-0Relevant articles and documents
Single-Step, Rapid, and Mild Synthesis of β-Amino Acid N-Carboxy Anhydrides Using Micro-Flow Technology
Sugisawa, Naoto,Otake, Yuma,Nakamura, Hiroyuki,Fuse, Shinichiro
, p. 79 - 84 (2020)
β-Amino acid N-carboxy anhydrides (β-NCAs) are rarely used in the synthesis of β-peptides, which is due mainly to the poor availability of these potentially useful substrates. Herein, we describe the heretofore challenging synthesis of β-NCAs via a single
Micro-flow synthesis of β-amino acid derivatives: Via a rapid dual activation approach
Fuse, Shinichiro,Nakamura, Hiroyuki,Sugisawa, Naoto
supporting information, p. 4527 - 4530 (2020/05/05)
Rapid dual activation (≤3.3 s) of both β-amino acid N-carboxy anhydride and alkyl chloroformate for the synthesis of a β-amino acid-derived scaffold was demonstrated. The key to success was the use of rapid mixing enabled by using a micro-flow reactor. Th
Synthesis of optically active β-amino acid N-carboxyanhydrides
Cheng, Jianjun,Ziller, Joseph W.,Deming, Timothy J.
, p. 1943 - 1946 (2007/10/03)
(Equation presented) Methodology has been developed for the general synthesis of optically active β-amino acid N-carboxyanhydrides (β-NCAs) through cyclization of Nβ-Boc or Nβ-Cbz β-amino acids using phosphorus tribromide. The format
