288623-94-9Relevant articles and documents
Synthesis of geometrically constrained unsymmetrical bis(polyamides) related to the antiviral distamycin
Sharma, Sanjay K.,Tandon, Manju,Lown, J. William
, p. 2095 - 2103 (2007/10/03)
Analysis of the structural and stereochemical requirements for the strict DNA base-sequence recognition of (AT)4 and (AT)5, respectively, for the oligopeptide minor-groove binding agents netropsin (I) and distamycin (II) leads to proposals for the rational structure modification for altered base recognition. In this paper we report the synthesis of unsymmetrical imidazo-pyrrolo-bis(polyamides), structurally related to the natural antiviral agents distamycin, and bearing either unnatural (25-27) or natural (31-33) termini linked by a flexible or rigid linker. This is the first report of the synthesis of an imidazole-bearing structure with either dimethylaminopropyl or amidinium termini in the linked bis(polyamides).