28885-64-5Relevant academic research and scientific papers
Synthesis of functionalized hydroquinones via [Cp*RuCl 2]2-catalyzed cocyclization of alkynes, α,β-unsaturated carbonyl compounds, and carbon monoxide
Fukuyama, Takahide,Yamaura, Ryo,Higashibeppu, Yuki,Okamura, Takahiro,Ryu, Ilhyong,Kondo, Teruyuki,Mitsudo, Take-Aki
, p. 5781 - 5783 (2005)
(Chemical Equation Presented) Catalytic [2 + 2 + 1 + 1] cocyclization reaction of an alkyne, an alkene, and two molecules of carbon monoxide, leading to functionalized hydroquinones, was studied. Using [Cp*RuCl 2]2 as a catalyst, we
Synthesis and antineoplastic activity of hydroquinone dialdehydes
Newman,Lin,Sartorelli
, p. 627 - 631 (2007/10/02)
A number of hydroquinone dialdehydes and structually related compounds were synthesized and tested for antineoplastic efficacy against transplanted murine tumors. 3,6-Dihydroxy-4,5-dimethylphthalaldehyde, 3,6-dihydroxy-4,5-dipropylphthalaldehyde, and 3,6-dihydroxy-4,5-dimethylphthalaldehyde hemialdal tetraacetate significantly prolonged the survival time of mice bearing either Sarcoma 180, Ehrlich carcinoma, or adenocarcinoma 755 ascites tumors. In addition, these agents were cytotoxic to Sarcoma 180 cells in culture at concentrations in the range of 25-30 μM.
