288852-06-2Relevant articles and documents
Synthesis of a six-carbon sialic acid using an indium-mediated coupling.
Chappell,Halcomb
, p. 2003 - 2005 (2000)
[reaction: see text] The synthesis of a six-carbon truncated sialic acid is described. A key step in the synthesis was an indium-mediated allyl addition to a serine-derived aldehyde. Careful choice of protecting groups was found to be necessary in order to prevent unwanted side reactions throughout the sequence. The truncated sialic acid was obtained in a form suitable for activation as a glycosyl donor.