28888-46-2

Basic information

• Product Name: methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)
• Synonyms: 6,9-Methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylicacid, 7-ethyl-7,8,9,10,12,13-hexahydro-, methyl ester, hydrochloride (1:1),(6R,6aR,7R,9S,11R)-rel-
• CAS NO: 28888-46-2
• Molecular Formula: C₂₁H₂₇ClN₂O₂
• Molecular Weight: 374.9043
• Mol File: 28888-46-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 488.1°C at 760 mmHg
• Flash Point: 249°C
• Vapor Pressure: 1.12E-09mmHg at 25°C
• CAS DataBase Reference: methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)(28888-46-2)
• EPA Substance Registry System: methyl (2alpha)-ibogamine-18-carboxylate hydrochloride (1:1)(28888-46-2)

Safety Data

• Hazardous Substances Data: 28888-46-2(Hazardous Substances Data)

Upstream product

• 1619235-78-7 C₂₂H₂₇N₃O₂ 
• 136118-90-6 methyl 4-cyano-5-ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino<5,4-b>indole-9-carboxylate 
• 341970-96-5 (+)-coronaridine 
• 2468-21-5 catharinthine 
• 38542-83-5 (+)-dihydrocatharanthine 

Relevant articles and documents

Synthesis of (-)-pseudotabersonine, (-)-pseudovincadifformine, and (+)-coronaridine enabled by photoredox catalysis in flow

Natural product modification with photoredox catalysis allows for mild, chemoselective access to a wide array of related structures in complex areas of chemical space, providing the possibility for novel structural motifs as well as useful quantities of less abundant congeners. While amine additives have been used extensively as stoichiometric electron donors for photocatalysis, the controlled modification of amine substrates through single-electron oxidation is ideal for the synthesis and modification of alkaloids. Here, we report the conversion of the amine (+)-catharanthine into the natural products (-)-pseudotabersonine, (-)-pseudovincadifformine, and (+)-coronaridine utilizing visible light photoredox catalysis.