2889-91-0Relevant academic research and scientific papers
Synthesis of NG-061 and its analogs, and their biological evaluation as an enhancer of nerve growth factor
Eguchi, Tadashi,Kanai, Shinobu,Kakinuma, Katsumi,Okazaki, Tadayasu,Mizoue, Kazutoshi
, p. 1470 - 1473 (2000)
A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was synthesized from methoxybenzoquinone and phenylacetylhydrazine in a single step. A series of acyl hydrazone derivatives were also synthesized and their potentiator activity of neurotrophic effect of NGF on neurite outgrowth was evaluated by assay with a rat pheochromocytoma cell line PC12.
