Chemical and Pharmaceutical Bulletin p. 1470 - 1473 (2000)
Update date:2022-08-04
Topics:
Eguchi, Tadashi
Kanai, Shinobu
Kakinuma, Katsumi
Okazaki, Tadayasu
Mizoue, Kazutoshi
A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was synthesized from methoxybenzoquinone and phenylacetylhydrazine in a single step. A series of acyl hydrazone derivatives were also synthesized and their potentiator activity of neurotrophic effect of NGF on neurite outgrowth was evaluated by assay with a rat pheochromocytoma cell line PC12.
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