28899-11-8Relevant articles and documents
Biosynthesis of the Antibiotic Obafluorin from p-Aminophenylalanine and Glycine (Glyoxylate)
Herbert, Richard B.,Knaggs, Andrew R.
, p. 109 - 114 (2007/10/02)
Results of experiments using 'resting' cells of Pseudomonas fluorescens with -, - and 2H2>-glycine as precursors show that glyoxylic acid is specifically the source of C-1 and C-2 of the antibiotic obafluorin 1.The 13C labelling patterns are consistent with the passage of the precursors through the tartronic semialdehyde and glyoxylate pathways.The glycine derivative 6 is not a precursor for 1.The analogues 24 and 25 of p-aminophenylalanine 3 are synthesised and tested as substrates for biosynthesis in P. fluorescens.With 24, the metabolite 26 is detected; no metabolites of 25 are detected.