28901-52-2Relevant academic research and scientific papers
Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors
Gallagher, Ryan,Qudah, Taima,Balle, Thomas,Chebib, Mary,McLeod, Malcolm D.
, (2021/11/27)
Analogues of methyllycaconitine (MLA) based on a (3-ethyl-9-methylidene-3-azabicyclo[3.3.1]nonan-1-yl)methanol template have been designed and synthesised that incorporate the modified ester sidechains distinct from that present in the natural product. Electrophysiology experiments using Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) revealed selected analogues served as non-competitive inhibitors that showed selectivity for the α4β2α7 nAChR subtypes, and selectivity for the (α4)3(β2)2(α4)2(β2)3 stoichiometry. This study more clearly defines the biological effects of MLA analogues and identifies strategies for the development of MLA analogues as selective ligands for the α4β2 nAChR subtype.
Palladium-Catalyzed Oxidative C–H Alkoxycarbonylation of Arenes with Alkylcarbazates Directed by N-Heterocyclic Substituents
Yogesh Kumar, Gujjenahalli Ramalingaiah,Begum, Noor Shahina
, p. 4698 - 4704 (2020/07/04)
With alkyl carbazates as the green ester source, a novel palladium-catalyzed oxidative free radical carbonylative transformation of the C–H bond on aromatic rings to produce esters has been developed. Good yields of the corresponding products have been obtained with wide functional group tolerance and excellent regioselectivity. A variety of alkyl carbazates are found to be suitable reactants for the ortho-alkoxycarbonylation on the aromatic ring.
Palladium-Catalyzed Oxidative Carbonylation of Aromatic C?H Bonds with Alcohols using Molybdenum Hexacarbonyl as the Carbon Monoxide Source
Wang, Zechao,Li, Yahui,Zhu, Fengxiang,Wu, Xiao-Feng
, p. 2855 - 2859 (2016/09/13)
With molybdenum hexacarbonyl as the carbon monoxide source, a general palladium-catalyzed carbonylative transformation of the C?H bond on aromatic rings to produce esters has been developed. Good yields of the corresponding products have been obtained with wide functional group tolerance and excellent regioselectivity. A variety of aliphatic alcohols are suitable reactants here. (Figure presented.).
Palladium-Catalyzed Decarboxylative Ortho-Ethoxycarbonylation of O-Methyl Ketoximes and 2-Arylpyridines with Potassium Oxalate Monoester
Li, Zhong-Yuan,Wang, Guan-Wu
supporting information, p. 4866 - 4869 (2015/10/12)
A novel method for introducing an ester group via palladium-catalyzed ligand-directed C-H activation has been explored. The ortho-ethoxycarbonylation of O-methyl ketoximes proceeded smoothly with the nontoxic and easily handled reagent potassium oxalate monoester, affording the desired products in moderate to good yields. Furthermore, pyridine could also be employed as a directing group to obtain similar results in this transformation.
Palladium-catalyzed direct alkoxycarbonylation of aromatic C-H bonds via selective C-C cleavage of a-keto esters
Zhou, Wei,Li, Pinhua,Zhang, Yicheng,Wang, Lei
, p. 2343 - 2352 (2013/10/01)
A novel palladium-catalyzed direct alkoxycarbonylation of 2-arylpyridines, 2-arylquinolines, benzo[h]quinolines, 2-phenylpyrimidines, N-pyrimidine pyrroles and N-pyrimidine indoles via aromatic C-H bond activation and selective C-C cleavage of a-keto esters has been developed. The method has the advantages of wide functional group tolerance, high selectivity, broad range of substrates and good yields.
New reactivity of oxaziridine: Pd(II)-catalyzed aromatic C-H ethoxycarbonylation via C-C bond cleavage
Peng, Xingao,Zhu, Yingguang,Ramirez, Thomas A.,Zhao, Baoguo,Shi, Yian
supporting information; experimental part, p. 5244 - 5247 (2011/12/04)
A novel Pd(II)-catalyzed aromatic C-H ethoxycarbonylation with oxaziridine involving C-C bond cleavage is described. Various aromatic 2-phenylpyridines and related compounds as well as aryl ureas can be effectively ethoxycarbonylated. A catalytic cycle in
Rhodium-catalyzed direct oxidative carbonylation of aromatic C#H bond with CO and alcohols
Guan, Zheng-Hui,Ren, Zhi-Hui,Liang, Yong-Min,Spinella, Stephen M.,Yu, Shichao,Zhang, Xumu
supporting information; experimental part, p. 729 - 733 (2009/06/23)
A general protocol for the rhodium-catalyzed oxidative carbonylation of arenes to form esters has been developed. A broad substrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heterocyclic arenes, and the reacti
Synthesis of functionalized 2-arylpyridines from 2-halopyridines and various aryl halides via a nickel catalysis
Gosmini, Corinne,Bassene-Ernst, Carine,Durandetti, Muriel
experimental part, p. 6141 - 6146 (2011/03/19)
An efficient nickel-catalyzed method devoted to the direct formation of functionalized 2-arylpyridines is described avoiding the prior preparation of organometallic species. Various functionalized 2-arylpyridines are obtained in moderate to excellent yields by a one-step chemical procedure from corresponding halides. The NiBr2(2,2′-bipyridine) complex appears to be an extremely suitable catalyst for the activation in the presence of manganese dust of aromatic halides and pyridyl halides functionalized by reactive groups. The versatility of this original process represents a simple alternative to most known methods using organometallic reagents.
Palladium-catalyzed oxidative ethoxycarbonylation of aromatic C-H bond with diethyl azodicarboxylate
Yu, Wing-Yiu,Wing, Nga Sit,Lai, Kin-Man,Zhou, Zhongyuan,Chan, Albert S. C.
, p. 3304 - 3306 (2008/10/09)
This communication describes the Pd(OAc)2-catalyzed ethoxycarbonylation reactions of aromatic C-H bonds using diethyl azodicarboxylate (DEAD) together with Oxone or K2S2O8. Substrates such as 2-arylpyridines, py
