2892-16-2Relevant articles and documents
Synthesis, experimental and theoretical study of novel 2-haloalkyl (-CF2H, -CCl2H, -CF2CF3)-, 3-bromo and bromomethyl substituted chromones
Narváez O, Ena G.,Bonilla V., Pablo M.,Zurita, Daniel A.,Alcívar L., Christian D.,Heredia-Moya, Jorge,Ulic, Sonia E.,Jios, Jorge L.,Piro, Oscar E.,Echeverría, Gustavo A.,Langer, Peter
, (2021)
A set of seven new chromones with 2-haloalkyl (-CF2H, -CCl2H, -CF2CF3) and 3-bromo and bromomethyl substituents were synthesized. The novel compounds were studied by DFT calculations and characterized by vibrational spectroscopy (IR and Raman) in solid state, and NMR (1H, 13C and 19F) and UV–vis spectroscopy in solution. The crystal structure of 3-dibromomethyl-2-difluoromethyl chromone was determined by X-ray diffraction. Due to extended π-bond delocalization, the organic framework is planar and lies on a crystallographic m-mirror plane. The intermolecular non-covalent interactions of 3-dibromomethyl-2-difluoromethyl chromone, as π?π stacking arrangements, F?H hydrogen bonds and O?Br contacts were evaluated by Hirshfeld surfaces analysis. These intermolecular contacts, which affect the absorption bands location of the involved groups, were also detected in the vibrational spectra.
Lewis acid promoted construction of chromen-4-one and isoflavone scaffolds via regio- and chemoselective domino Friedel-Crafts acylation/Allan-Robinson reaction
Chanda, Tanmoy,Chowdhury, Sushobhan,Koley, Suvajit,Anand, Namrata,Singh, Maya Shankar
supporting information, p. 9216 - 9222 (2014/12/11)
A facile and efficient synthesis of chromen-4-one and isoflavone frameworks is achieved by the domino C-acylation/O-acylation/aldolization sequence. This operationally simple one-pot elegant strategy provides structurally unique chromen-4-ones and isoflavones directly from phenols via concomitant formation of multiple C-C and C-O bonds in a single operation. The outcomes of the buttressing effect, substituent dependence, and catalyst and solvent specificity during the course of the Friedel-Crafts acylation reactions are demonstrated and supported by fitting experiments.
Flavanonol derivatives and hair-nourishing, hair growing compositions containing the derivatives
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, (2008/06/13)
The present invention relates to flavanonol derivatives represented by formula (1): STR1 (wherein R1 represents an alkyl group, and each of R2 and R3 represents a hydrogen atom, an alkyl group which may have a substituent,