68597-44-4Relevant academic research and scientific papers
Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants
Shiozawa,Narita,Izumi,Kurashige,Sakitama,Ishikawa
, p. 85 - 94 (2007/10/02)
Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.
ACYLATION OF CHLOROANISOLES
Yuldashev, Kh. Yu.
, p. 1610 - 1612 (2007/10/02)
In the reaction of 2-, 3-, and 4-chloroanisoles with the chlorides and anhydrides of acetic, propionic, and 4-substituted benzoic acids in the presence of 1E-3 mole of ferric chloride 35-80percent of the ketone fraction was obtained.Under the reaction con
