2892-63-9

Basic information

• Product Name: 3,4-DICHLOROCYCLOBUT-3-ENE-1,2-DIONE
• Synonyms: 3,4-Dichloro-3-cyclobutene-1,2-dione;Squaric acid dichloride;3,4-dichlorocyclobut-3-ene-1,2-quinone;1,2-Dichloro-1-cyclobutene-3,4-dione;Dichlorocyclobutenedione;Quadratic acid dichloride;Squaryl dichloride;3-Cyclobutene-1,2-dione,3,4-dichloro-
• CAS NO: 2892-63-9
• Molecular Formula: C₄Cl₂O₂
• Molecular Weight: 150.95
• Product Categories: Halides;Ring Systems
• Mol File: 2892-63-9.mol
• Article Data: 32

Chemical Properties

• Melting Point: 51-52℃
• Boiling Point: 175.6°Cat760mmHg
• Flash Point: 66°C
• Appearance: /
• Density: 1.74g/cm³
• Vapor Pressure: 1.14mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: 3,4-DICHLOROCYCLOBUT-3-ENE-1,2-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLOROCYCLOBUT-3-ENE-1,2-DIONE(2892-63-9)
• EPA Substance Registry System: 3,4-DICHLOROCYCLOBUT-3-ENE-1,2-DIONE(2892-63-9)

Safety Data

• Hazardous Substances Data: 2892-63-9(Hazardous Substances Data)

Usage

General Description

3,4-Dichlorocyclobut-3-ene-1,2-dione is a chemical compound more commonly known under its systematic name, dichlorodimethyl cyclobutene-1,2-dione. With the molecular formula C4H2Cl2O2, it falls under the class of organochlorine compounds. These compounds are characterized by the presence of chlorine. Specific details about its applications or use are not readily available but, like other organochlorine substances, it could potentially be used in industries or laboratories where chemical reactions are involved. Decoding its name, it suggests that the chemical contains a cyclobutene ring (four carbon ring) with two chlorine and two oxygen atoms. The safety, toxicity, and environmental impact of this specific chemical are not documented extensively, which is common for specialized and lesser-known chemical compounds.

InChI:InChI=1/C4Cl2O2/c5-1-2(6)4(8)3(1)7

Upstream product

• 79-37-8 oxalyl dichloride 
• 2892-51-5 squaric acid 
• 3200-96-2 2,3,4,4-tetrachloro-cyclobut-2-en-1-one 

Downstream Products

• 68239-27-0 3-Chlor-4-morpholino-3-cyclobuten-1,2-dion 
• 102268-26-8 C₁₃H₁₃NO₃ 
• 147933-02-6 3-chloro-4-phenacylcyclobut-3-ene-1,2-dione 
• 137502-10-4 2,3-dichloro-4-hydroxy-4-phenacylcyclobut-2-enone 
• 137502-11-5 4-(1-benzoylethyl)-2,3-dichloro-4-hydroxycyclobut-2-enone 
• 37669-68-4 3-Chlor-4-(dimethylamino)-3-cyclobuten-1,2-dion 
• 146040-19-9 4-(3-carbethoxypropyl)-3-cyclohexylcyclobutene-1,2-dione 
• 102268-50-8 1-(2-Hydroxy-3,4-dioxo-cyclobutenyl)-triphenylarsonium-betain 
• 147933-03-7 3-chloro-4-(2-oxocyclohexyl)cyclobut-3-ene-1,2-dione 
• 147932-91-0 2-(2,3-dichloro-1-hydroxy-4-oxocyclobut-2-enyl)cyclohexanone 
• 97962-52-2 3-(N-Benzylanilino)-4-chlor-3-cyclobuten-1,2-dion 
• 146040-13-3 3,4-Bis-(1-phenyl-ethyl)-cyclobut-3-ene-1,2-dione 
• 146040-18-8 3,4-Bis-(4-oxo-4-phenyl-butyl)-cyclobut-3-ene-1,2-dione 
• 137502-13-7 3-chloro-4-(1-benzoyl-1-methylethyl)cyclobut-3-ene-1,2-dione 

Relevant articles and documents

Water-driven chemoselective reaction of squarate derivatives with amino acids and peptides

(Chemical Equation Presented) Here, we report a new class of highly chemoselective reactions between squarate derivatives and the amino acid cysteine or unprotected peptides with a N-terminus cysteine that proceed most efficiently in entirely aqueous solu

Heterotriangulene-based unsymmetrical squaraine dyes: synergistic effects of donor moieties and out-of-plane branched alkyl chains on dye cell performance

Unsymmetrical squaraine sensitizers with two different donor moieties, triphenylamine (NSQR) and heterotriangulene (NSQ1-3), for dye-sensitized solar cells (DSSCs) have been designed and synthesized. These dyes utilize the indolium moiety to control charge recombination dynamics at the TiO2-dye-electrolyte interface by connecting linear and branched alkyl functionalities. In the present study, an efficient heterotriangulene (HT) donor and a branched alkyl group at sp3-C atoms were strategically incorporated to increase the power conversion efficiency (PCE) of zwitterionic dyes by improving photo-current density (Jsc) and open-circuit potential (Voc) of the cell. Among these four dyes, NSQ3 exhibited the highest efficiency of 6.73% with a Jsc of 18.74 mA cm?2, Voc of 0.53 V, and fill factor (ff) of 68.3%, without any co-adsorbent under an irradiance of 100 mW cm?2 (simulated AM 1.5G sunlight). In the presence of 3α,7α-dihydroxy-5β-cholanic acid (CDCA), NSQ1, NSQ2 and NSQ3 showed an efficiency of 7.07%, 7.38% and 7.17%, respectively. Despite the low Voc, far red light harvesting efficiency, reduced dye aggregation, long lifetime (τ) of injected electrons and high quantum efficiency of NSQ1-3 played constructive roles in achieving high PCE efficiency. Deceleration of charge recombination for NSQ dye cells was further studied by electrochemical impedance spectroscopy (EIS) and open-circuit photo-voltage decay (OCVD) measurements.

Synthesis and antiplasmodial activity of bisindolylcyclobutenediones

Malaria is one of the most dangerous infectious diseases. Because the causative Plasmod-ium parasites have developed resistances against virtually all established antimalarial drugs, novel antiplasmodial agents are required. In order to target plasmodial

Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy

Increasing evidence shows that the CXC chemokine receptor 2 (CXCR2) signaling pathway is essentially implicated in the recruitment of myeloid-derived suppressor cells (MDSCs) to the tumor microenvironment and leads to MDSC-mediated immune suppression. Therefore, CXCR2 has recently emerged as a promising drug target for cancer immunotherapy. In this paper, benzocyclic sulfone derivatives were designed as potent CXCR2 antagonists. Structure-activity relationship studies resulted in two lead compounds 9b and 11h, which demonstrated double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch in an in vivo setting. More importantly, 9b and 11h dose-dependently inhibited the tumor growth through oral administration in the Pan02 mouse model. Further cytometry and immunohistochemical analyses revealed that 9b and 11h could reduce the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues, shedding light on their mechanisms of action in cancer immunotherapy.

NOVEL OXADIAZOLE COMPOUNDS FOR CONTROLLING OR PREVENTING PHYTOPATHOGENIC FUNGI

The present invention discloses a compound of formula (I), wherein, R1, L1,A, k, L2, W, L4, R5, R8 and R9 are as defined in the detailed description. The present invention furthe