28944-95-8Relevant articles and documents
The method of preparation of enantiomerically enriched products of condensation from racemic acids or acids of the low enentiomeric purity
-
Page/Page column 7, (2012/03/08)
The method of obtaining enantiomerically enriched condensation products consists of subjecting a racemic acid or an acid of low enantiomeric purity to the action of a condensing reagent - a chiral N-triazinylammonium tetrafluoroborate (formula 1), a chira
The design, synthesis, and application of a chiral coupling reagent derived from strychnine for the enantioselective activation of a carboxylic group
Kolesińska, Beata,Kasperowicz, Katarzyna,Sochacki, Marek,Mazur, Adam,Jankowski, Stefan,Kamiński, Zbigniew J.
supporting information; experimental part, p. 20 - 22 (2010/03/03)
The concept of a chiral coupling reagent for the enantioselective synthesis of peptides with a predictable configuration and enantiomeric purity from racemic substrates is presented. The reagent was prepared by treatment of strychninium tetrafluoroborate with 2-chloro-4,6-dimethoxy-1,3,5-triazine in the presence of sodium bicarbonate yielding N-(4,6-dimethoxy-1,3,5-triazin-2-yl)strychninium tetrafluoroborate in high yield, which is stable at room temperature, and in a broad range of solvents gave enriched Z-Ala-Phe-OMe (dr from 95/5 to 60/40) in high yield with d-configuration on the alanine residue starting from rac-Z-Ala-OH.
