289471-92-7

Usage

Uses

Used in Pharmaceutical Industry:
4-Iodo-2-(phenylMethoxy)phenol is used as an intermediate in the synthesis of isotope-labeled compounds, specifically for the preparation of isotope-labeled Quercetin (Q509500) conjugates. This application is significant in the development of new drugs and the study of biological processes, as isotope labeling allows for the tracking and analysis of these compounds within biological systems.
Used in Chemical Research:
4-Iodo-2-(phenylMethoxy)phenol can also be utilized in chemical research as a starting material for the synthesis of various complex organic molecules. Its unique structure makes it a valuable building block for the creation of novel compounds with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 120-80-9 benzene-1,2-diol 
• 100-44-7 benzyl chloride 
• 6272-38-4 O-benzylcatechol 

Downstream Products

• 289471-95-0 1-iodo-3-benzyloxy-4-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)benzene 
• 872410-24-7 1-benzyloxy-2-decyloxy-5-iodobenzene 
• 872410-29-2 2-benzyloxy-4-iodophenyl acetate 
• 122769-75-9 (S)-benzyl 3-(3-(benzyloxy)-4-hydroxyphenyl)-2-(((benzyloxy)carbonyl)amino)propanoate 
• 872410-34-9 2'-benzyloxy-4-hexyloxy-4''-hexadecyloxy-p-terphenyl 
• 872410-35-0 2'-benzyloxy-4-hexadecyloxy-4''-hexyloxy-p-terphenyl 
• 872410-25-8 3-benzyloxy-4,4''-didecyloxy-p-terphenyl 
• 872410-33-8 3-benzyloxy-4'-hexadecyloxybiphenyl-4-yl trifluoromethanesulfonate 
• 872410-31-6 3-benzyloxy-4'-hexadecyloxybiphenyl-4-ol 
• 872410-32-7 3-benzyloxy-4'-hexyloxybiphenyl-4-yl trifluoromethanesulfonate 
• 872410-30-5 3-benzyloxy-4'-hexyloxybiphenyl-4-ol 

Relevant academic research and scientific papers

CARBIDOPA AND L-DOPA PRODRUGS AND THEIR USE TO TREAT PARKINSON'S DISEASE

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

Carbohydrate rod conjugates: Ternary rod-coil molecules forming complex liquid crystal structures

T-shaped polyphilic triblock molecules, consisting of a rodlike p-terphenyl unit, a hydrophilic and flexible laterally attached oligo(oxyethylene) chain terminated by an 1-acylamino-1-deoxy-D-sorbitol unit, and two end-attached lipophilic alkyl chains, have been synthesized by palladium-catalyzed cross-coupling reactions as the key steps. The thermotropic liquid crystalline behavior of these compounds was investigated by polarized light microscopy, differential scanning calorimetry (DSC), and X-ray scattering. We investigated the mode of self-organization as a function of the length and position of the lateral polar chain and the length of the terminal alkyl chains. Depending on the size of the polar and lipophilic segments, a series of unusual liquid crystalline phases was detected. In three of these phases, the space is divided into three distinct periodic subspaces. In addition to a hexagonal channeled layer phase (ChLhex) consisting of layers that are penetrated by polar columns, there are also two honeycomb-like network structures formed by square (Colsqu/p4mm) or pentagonal cylinders (Colsqu/p4gm) . The cylinder walls consist of the terphenyl units fused by columns of alkyl chains, and the interior contains the polar side chains. In addition, a hexagonal columnar phase was observed in which the polar columns are organized in a continuum of terphenyls and alkyl chains with an organization of the terphenyl cores tangentially around the columns with the long axis perpendicular to the columns. For one compound, a reversal of birefringence was observed, which is explained by a reorientation of the terphenyl cores. The addition of protic solvents induces lamellar phases.

Isotopic labelling of Quercetin 4'-O-β-D-glucoside

[2-13C]-Quercetin-4'-O-β-glucoside was synthesised in four steps and 28% yield from barium [13C]-carbonate. This short route will be applicable to the synthesis of radiolabelled quercetin-4'-O-β-D-glucoside from barium [14