289495-41-6

Upstream product

• 289495-39-2 2-tert-butoxycarbonylmethoxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 289495-38-1 1-tert-butyloxycarbonyl-(2R,4S)-4-(tert-butyldimethylsilyl-oxy)proline ethyl ester 
• 134441-72-8 1,1-dimethylethyl (2R,4S)-4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate 
• 77450-02-3 N-(tert-butoxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 4330-20-5 N-3-benzoylthymine 
• 289495-40-5 N-α-tert-butyloxycarbonyl-(2R,4S)-2-tert-butyloxycarbonylmethoxymethyl-4-hydroxy-pyrrolidine 

Relevant academic research and scientific papers

Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoammino acids

Nδ-Fmoc protected nucleoamino acids of type I (base=T, C, A) have been synthesized and employed as building blocks for the construction of novel polyamide based nucleic acid analogues. Homopyrimidine oligomer A binds to complementary RNA with significant affinity and in a sequence-specific fashion, while no binding was observed to complementary DNA. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis of pyrrolidine-based oxy-peptide nucleic acids carrying four types of nucleobases and their transport into cytoplasm

We synthesized 16 pyrrolidine-based oxy-peptide nucleic acid (POPNA) monomers carrying four different nucleobases onto four different stereoisomers of pyrrolidine rings. Using these monomers, we prepared POPNA oligomers, which formed sequence-specific hyb